High rate of antiretroviral drug resistance mutations in HIV type 1-infected Senegalese children in virological failure on first-line treatment according to the World Health Organization guidelines.
PMID: 22860571
2013
AIDS research and human retroviruses
Abstract: The NRTI-resistant viruses harbored the M184V/I (95%), Q151M (2%), and thymidine-analogue mutations (40%), and the NNRTI-resistant viruses harbored the K103N (34%), Y181C (32%), G190A (23%), and K101E (21%) mutations.
Differential in vitro kinetics of drug resistance mutation acquisition in HIV-1 RT of subtypes B and C.
Abstract: RT subtype B virus isolates tended to acquire different ZDV resistance mutations (Q151M and D67N or T215Y, D67D/N and F214L) compared to subtype C (D67N, K70R, T215I or T215F).
Introduction: Q151M-associated mutations confer resistance to all nucleoside reverse transcriptase inhibitors (
Introduction: Many resistance mutations have already been characterized including three multi-drug resistance profiles (insertions at codon 69, Q151M-mediated multinucleoside resistance and thymidine analogue mutations (TAM)).
Biochemical, inhibition and inhibitor resistance studies of xenotropic murine leukemia virus-related virus reverse transcriptase.
Abstract: We demonstrated that XMRV RT mutants K103R and Q190M, which are equivalent to HIV-1 mutants that are resistant to tenofovir (K65R) and AZT (Q151M), are also resistant to the respective drugs, suggesting that XMRV can acquire resistance to these compounds through the decreased incorporation mechanism reported in HIV-1.
Result: Since AZT and tenofovir are potent inhibitors of XMRV (Table 6), we wanted to investigate whether the XMRV Discussion: In HIV, decreased binding of AZT is conferred initially in the presence of the primary Q151M mutation, followed by secondary mutations F77L, A62V, V75I and F116Y.
Reverse transcriptase genotypes in pediatric patients failing initial antiretroviral therapy in Gaborone, Botswana.
PMID: 21972264
2012
Journal of the International Association of Physicians in AIDS Care (Chicago, Ill.
Chemical system biology based molecular interactions to identify inhibitors against Q151M mutant of HIV-1 reverse transcriptase.
PMID: 22027876
2012
Journal of acquired immune deficiency syndromes (1999)
Abstract: S68G, T165I, and I202V were associated with Q151M
Abstract: BACKGROUND: We hypothesized that polymorphic mutations exist that are associated with the emergence of the multinucleoside resistance mutations (MNR), 69 insertion and Q151M.
Abstract: Logistic regression showed that F214L and V60I were associated with the emergence of Q151M/TAM 2 opposed to 69 insertion/TAM 1.
Abstract: METHODS: The Swiss HIV Cohort Study was screened, and the frequencies of polymorphic mutations in HIV-1 (subtype B) were compared between patients detected with the 69 insertion (n = 17), Q151M (n = 29), >=2 thymidine analogue mutations (TAM) 1 (n = 400) or >=2 TAM 2 (n = 249).
Low rates of nucleoside reverse transcriptase inhibitor resistance in a well-monitored cohort in South Africa on antiretroviral therapy.
Abstract: Thymidine analogue mutations were infrequent (1%) and Q151M was not observed.
Introduction: A large proportion of these patients harboured mutations associated with cross-resistance to most Result: Only one subject had TAMs and Q151M was not observed.
Result: TAMS were infrequent (1%) and Q151M was not observed (Figure 1).
Discussion: Furthermore, only one participant in this study harbored TAMs, in complete contrast to all other published studies from the region which report levels of 23% to 56% and the Q151M mutation was not observed.
Discussion: The mutations K65R and TAMs were observed infrequently, and the Q151M was not present at all, thereby preserving the use of AZT, ddI or TNF used in second-line regimens.
Low prevalence of transmitted drug resistance in patients newly diagnosed with HIV-1 infection in Sweden 2003-2010.
Result: Only two samples (455 and 493) bore a K65R mutation, one (455) cumulating K65R and the Q151M nucleoside analog mutation (NAM).
Discussion: Second, there is an antagonism between TAMs and K65R, while the latter can be found in association with NAMs (Q151M) and is considered to be increasingly selected in the presence of DRMs to NNRTIs and particularly Y181C and G190A.
Effect of translocation defective reverse transcriptase inhibitors on the activity of N348I, a connection subdomain drug resistant HIV-1 reverse transcriptase mutant.
PMID: 23273211
2012
Cellular and molecular biology (Noisy-le-Grand, France)
8Discussion: The A62V/V75I/F77L/F116Y/Q151M set of mutations is known as the ""Q151M"" complex RT, and has been known as a multidrug-resistance mutation, since the latter mutations are known to be involved in resistant variants with reduced susceptibility to dideoxynucleotides and to AZT."
Discussion: Unlike D67N/K70R/L210Q/T215F RT, the Q151M complex decreases susceptibility to NRTIs by decreasing incorporation efficiency of the inhibitors rather than increasing excision and unblocking of chain-ter
Monitoring HIV viral load in resource limited settings: still a matter of debate?
HIV mutation literature information.
PMID: 
2013
AIDS research and human retroviruses
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