Nucleoside reverse transcriptase inhibitor resistance mutations associated with first-line stavudine-containing antiretroviral therapy: programmatic implications for countries phasing out stavudine.
PMID: 23687292
2013
The Journal of infectious diseases
Abstract: Longer therapy increased the risk of TAMs and Q151M but not K65R.
Abstract: Mutations with preferential tenofovir activity, >= two thymidine analog mutations (TAMs) or Q151M, occurred in 22% of individuals.
Abstract: Nevirapine increased the risk of TAMs, K65R, and Q151M.
Abstract: Subtype C and CRF01_AE increased the risk of K65R, but only CRF01_AE increased the risk of K65R without Q151M.
Restriction fragment mass polymorphism (RFMP) analysis based on MALDI-TOF mass spectrometry for detecting antiretroviral resistance in HIV-1 infected patients.
PMID: 23480551
2013
Clinical microbiology and infection
Abstract: The concordance rates between the RFMP and direct sequencing assays for the examined codons were 97% (K65R), 97% (T69Ins/D), 97% (L74VI), 97% (K103N), 96% (V106AM), 97% (Q151M), 97% (Y181C), 97% (M184VI) and 94% (T215YF) in the reverse transcriptase coding region, and 100% (D30N), 100% (M46I), 100% (G48V), 100% (I50V), 100% (I54LS), 99% (V82A), 99% (I84V) and 100% (L90M) in th
Transmission patterns of HIV-subtypes A/AE versus B: inferring risk-behavior trends and treatment-efficacy limitations from viral genotypic data obtained prior to and during antiretroviral therapy.
Result: Specific NRTI mutations that were accurately reproduced include K65R, Q151M, and T215Y, while mutations M41L and M184V are slightly underestimated, compared to previous studies.
HIV-1 drug resistance and associated factors among adults failing first-line highly active antiretroviral therapy in Ho Chi Minh City, Vietnam.
Abstract: The proportions of K65R, Q151M, and T69 insertion were 13%, 11%, and 5%, respectively.
Antiviral resistance and correlates of virologic failure in the first cohort of HIV-infected children gaining access to structured antiretroviral therapy in Lima, Peru: a cross-sectional analysis.
Method: The OLA was conducted according to the NIH protocol for mutations at HIV-1B protease positions D30N, I50V, V82A, V82S, V82T, I84V, N88D, and L90M as well as reverse transcriptase positions K103N, Y181C, K65R, T215F, T215Y, M184V, and Q151M.
High rate of antiretroviral drug resistance mutations in HIV type 1-infected Senegalese children in virological failure on first-line treatment according to the World Health Organization guidelines.
PMID: 22860571
2013
AIDS research and human retroviruses
Abstract: The NRTI-resistant viruses harbored the M184V/I (95%), Q151M (2%), and thymidine-analogue mutations (40%), and the NNRTI-resistant viruses harbored the K103N (34%), Y181C (32%), G190A (23%), and K101E (21%) mutations.
From the chemistry of epoxy-sugar nucleosides to the discovery of anti-HIV agent 4'-ethynylstavudine-Festinavir.
Introduction: Moreover, the strains carrying the K65R or the Q151M complex were still susceptible to 4'-ethynylstavudine.
Introduction: The K65R mutation confers resistance to tenofovir and some NRTIs and, the Q151M complex (A62V, V75I, F77L, F116Y, and Q151M) confers resistance to most of the clinically approved NRTIs.
Introduction: While zidovudine, stavudine, didanosine, and lamivudine were 440-, 8.4-, 14- and 2.8-fold less active against the Q15M mutant of HXB-2, respectively, 4'-ethynyl-stavudine retained potent anti-HIV-1 activity against the mutants harborin
Mechanism of resistance to S138A substituted enfuvirtide and its application to peptide design.
PMID: 23357451
2013
The international journal of biochemistry & cell biology
Discussion: For example, in the case of the most commonly used drugs that target HIV reverse transcriptase (RT), the virus can develop multidrug resistance by either the Q151M complex pathway or by accumulation of thymidine associated mutations (TAMs).
Antiretroviral drug resistance profiles and response to second-line therapy among HIV type 1-infected Ugandan children.
PMID: 23308370
2013
AIDS research and human retroviruses
Abstract: TAMs,>=3 TAMs, 69 insertion complex, K65R/N, and Q151M were observed in 43.0%, 10.6%, 18.3%, 2.8%, and 2.1% of the children, respectively.
HIV mutation literature information.
PMID: 
2013
The Journal of infectious diseases
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