Abstract: We show here that four mutations (Y115F, M184V, M184I, and Q151M) in the dNTP-binding pocket of RT that had relatively small effects on the overall HIV-1 mutation rate (less than 3-fold compared to the wild type) significantly increased mutations at some specific positions in the lacZalpha reporter gene.
High-level cross-resistance to didanosine observed in South African children failing an abacavir- or stavudine-based 1st-line regimen.
Result: The Q151M mutation was only detected in 2 ABC-exposed children (2.5%) and 6 d4T-exposed children (2.2%).
Emergence of drug resistance in human immunodeficiency virus type 1 infected patients from pune, India, at the end of 12 months of first line antiretroviral therapy initiation.
Abstract: However, direct associations of K70S with mutations within the Q151M-complex and of K70T with K65R were observed.
Abstract: In vitro phenotypic testing revealed only minor effects of K70R/S/T as single mutations, associated with Q151M and within the context of the Q151M-complex.
2014 Update of the drug resistance mutations in HIV-1.
Discussion: Q151M is the most important mutation in the complex (ie, the other mutations in the complex [A62V, V75I, F77L, and F116Y] in isolation may not reflect multidrug resistance).
Discussion: Tenofovir retains activity against the Q151M complex of mutations.
The lysine 65 residue in HIV-1 reverse transcriptase function and in nucleoside analog drug resistance.
Introduction: Data from this study shows that while K65R was present in 82% of genomes without TAMs, and at low frequency in the presence of <3 TAMs; no sequences were identified with K65R, T215F/Y and >= 2 TAMs in the absence of the Q151M multi-drug resistant complex.
Introduction: Q151 is mutated to methionine (Q151M) in response to treatment with dideoxynucleoside analogs and usually occurs in combination with A62V, V75I, F77L, and F116Y mutations.
Introduction: The association of Q151M and other Q151M complex mutations with K65R,
A uniquely prevalent nonnucleoside reverse transcriptase inhibitor resistance mutation in Russian subtype A HIV-1 viruses.
Result: The multi-NRTI resistance mutation Q151M occurred in two patients receiving both thymidine-analog and nonthymidine-analog containing regimens.
Discussion: Although A62V alone does not reduce NRTI susceptibility, it is an accessory utation that frequently co-occurs with K65R and Q151M, mutations responsible for multi-NRTI resistance.
HIV multi-drug resistance at first-line antiretroviral failure and subsequent virological response in Asia.
PMID: 25141905
2014
Journal of the International AIDS Society
Abstract: There were 97/105 (92%) patients harbouring >= 1 RAMs at first-line failure, 39/105 with multi-NRTI RAMs: six with Q151M; 24 with >= 2 TAMs; and 32 with M184V+>= 1 TAM.
Abstract: Three patterns, including thymidine analogue mutations (TAMs), 69 Insertion (69Ins) and the Q151M complex, are associated with resistance to multiple-nucleoside reverse transcriptase inhibitors (NRTIs) and may compromise treatment options for second-line ART.
Abstract: We defined multi-NRTI RAMs as the presence of either Q151M; 69Ins; >= 2 TAMs; or M184V+>= 1 TAM.
Discussion: Six patients had Q151M, 24 had >=2 TAMs and 32 had
Virological failure and HIV-1 drug resistance mutations among naive and antiretroviral pre-treated patients entering the ESTHER program of Calmette Hospital in Cambodia.
Abstract: Two (13.3%) pre-treated patients harbored viruses that showed a multi-nucleos(t)ide resistance including Q151M, K65R, E33A/D, E44A/D mutations.
Method: Multidrug resistance was defined as the presence of K65R, Q151M, or at least three TAMs.
Result: Multi-Nucleos(t)ide Resistance (MNR) were only observed in pre-treated patients, including 2 (13.3%) harboring Q151M, K65R, E33A/D, E44A/D mutations.
Significantly improved HIV inhibitor efficacy prediction employing proteochemometric models generated from antivirogram data.
Result: Specific NRTI mutations that were accurately reproduced include K65R, Q151M, and T215Y, while mutations M41L and M184V are slightly underestimated, compared to previous studies.
HIV mutation literature information.
PMID: 
2014
Journal of virology
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