literature

HIV mutation literature information.

Distinct Pattern of Thymidine Analogue Mutations with K65R in Patients Failing Tenofovir-Based Antiretroviral Therapy.

PMID: 29084434 2018 AIDS research and human retroviruses

Introduction: As expected, patients failing AZT-based therapy did not develop mutations K65R, K70E, L74V, or Y115F, and only rarely were DRMs from the Q151M complex seen.

Introduction: However, in the 31 patients with no K65R present at S2, 6 had intermediate or high-level resistance to AZT: 4 were caused by TAM-2 DRMs, 1 by T215Y, and 1 by Q151M-complex mutations Q151M, A62V, V75I, F77L, F116Y.

Fidelity of classwide-resistant HIV-2 reverse transcriptase and differential contribution of K65R to the accuracy of HIV-1 and HIV-2 reverse transcriptases.

PMID: 28333133 2017 Scientific reports

Abstract: In HIV-2, resistance to all approved nucleoside analogues is conferred by the combination of RT substitutions K65R, Q151M and M184V.

Abstract: We have determined the intrinsic fidelity of DNA synthesis of WT HIV-2 RT and mutants K65R and K65R/Q151M/M184V.

Introduction: An estimated prevalence of 9% has been reported for the combination of K65R, Q151M and M184V in a European cohort of HIV-2-infected patients treated with antiretroviral drugs.

Introduction: By themselves, amino acid substitutions K65R,

PMID: 28099515 2017 PloS one

Table: Q151M

HIV Drug Resistance Mutations in Non-B Subtypes After Prolonged Virological Failure on NNRTI-Based First-Line Regimens in Sub-Saharan Africa.

PMID: 28129253 2017 Journal of acquired immune deficiency syndromes (1999)

Abstract: In general, DRMs were more common in subtype-C than in subtype-A and/or subtype-D (nucleoside reverse transcriptase inh

Result: In particular, Q151M was seen in 10% of the subtype-C vs <1% of subtype-A/subtype-D.

Result: Supplemental Digital Content, Table 1a, http://links.lww.com/QAI/A970), type-2 thymidine analog DRMs were more common in A and C than in D, K65R and Q151M were more common in C than in both A and D (K65R was more common in A than in D), whereas L210W was less common in C than in both A and D.

Evolution of tenofovir-resistant HIV-1 isolates exposed to tenofovir alafenamide dose escalation.

PMID: 28363735 2017 Antiviral research

Abstract: Resistance selection experiments using HIV-1 isolates harboring pre-existing tenofovir (TFV)-resistance (K65R, 3TAMs, and Q151M complex) were carried out with the novel tenofovir prodrug tenofovir alafenamide (TAF) as well as with tenofovir (TFV), to investigate the potential for additional resistance development in the presence of TAF or TFV.

HIV drug resistance in HIV positive individuals under antiretroviral treatment in Shandong Province, China.

PMID: 28750025 2017 PloS one

Table: Q151M

Chemical system biology based molecular interactions to identify inhibitors against Q151M mutant of HIV-1 reverse transcriptase.

PMID: 28396546 2017 Antimicrobial agents and chemotherapy

Abstract: Q151M and four associated mutations, A62V, V75I, F77L, and F116Y, were detected in patients failing therapies with dideoxynucleosides (didanosine [ddI], zalcitabine [ddC]) and/or zidovudine (AZT).

Abstract: The cluster of the five mutations is referred to as the Q151M complex (Q151Mc), and an RT or virus containing Q151Mc exhibits resistance to multiple NRTIs.

Abstract: The single mutation Q151M introduces conformational perturbation at the deoxynucleoside triphosphate (dNTP)-binding pocket, and the mutated pocket may exist in multiple conformations.

Week 48 resistance analysis of Elvitegravir/Cobicistat/Emtricitabine/Tenofovir DF versus Atazanavir + Ritonavir + Emtricitabine/Tenofovir DF in HIV-1 infected women (WAVES study GS-US-236-0128).

PMID: 28891788 2017 HIV clinical trials

Method: Primary NRTI-R substitutions assessed were M41L, A62V, K65R, D67N, T69 insertions, K70E/R, L74I/V, V75I, F77L, Y115F, F116Y, Q151M, M184V/I, L210W, T215F/Y, and K219E/N/Q/R in RT.

Upward trends of acquired drug resistances in Ethiopian HIV-1C isolates: A decade longitudinal study.

PMID: 29049402 2017 PloS one

Result: Mutations conferring multi-drug resistance such as Q151M and T69ins were not detected.

High level of HIV-1 drug resistance mutations in patients with unsuppressed viral loads in rural northern South Africa.

PMID: 28750647 2017 AIDS research and therapy

Result: A62V often occurs in combination with multi-resistance NRTI mutations K65R and Q151M.

Result: In this study, all the A62V mutations described were linked to K65R, but not to Q151M.

Result: The Q151M multi-drug resistant mutation was found in one subject while the transitional mutation (Q151L) which precedes the emergence of Q151M was observed in 2 patients.

Browser Board

Co-occurred Entities

Filtrator