PMID: 19572425
2008
Enfermedades infecciosas y microbiologia clinica
Abstract: The most common resistance pattern seems to be E138K + E147G + Q148R.
Abstract: The most frequently observed mutations in failure with elvitegravir are E92Q, E138K, Q148R/K/H and N155H, and less frequently S147G and T66A/I/K.
Changes to the HIV long terminal repeat and to HIV integrase differentially impact HIV integrase assembly, activity, and the binding of strand transfer inhibitors.
PMID: 17715137
2007
The Journal of biological chemistry
Abstract: 3) The strand transfer and inhibitor binding defects of a Q148R mutant are due to a decreased affinity of the complex for magnesium.
HIV mutation literature information.
PMID: 
2008
Enfermedades infecciosas y microbiologia clinica
Browser Board
Co-occurred Entities
Filtrator