The frequency of defective genes in vif and vpr genes in 20 hemophiliacs is associated with Korean Red Ginseng and highly active antiretroviral therapy: the impact of lethal mutations in vif and vpr genes on HIV-1 evolution.
Abstract: Q135P in the vif gene is significantly associated with rapid progression to AIDS (p < 0.01).
Result: Q135P in the vif gene is associated with rapid progression to AIDS.
Result: Q135P was detected in nine patients including Plasma Donor O.
Result: Interestingly, survival analysis revealed that Q135P was significantly associated with fast progression to AIDS, although K22N was not associated with it.
Result: Of note, in HP 17, Q135P developed during GCT.
HIV mutation literature information.
PMID: 
2021
Journal of ginseng research
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