Result: These results indicate that the HLA-B*51:01-adapted Y120F/Q125H mutations selectively impaired Nef's ability to counteract SERINC3/5 but that CD4, CCR5, CXCR4 and HLA downregulation functions and CD74 upregulation function remained unaffected.

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Discussion: The highly conserved D123 residue (> 99% prevalence in subtype A, B, C and D) is encompassed by the immune-escape mutation sites of Y120F and Discussion: We have demonstrated here that a number of naturally-occurring Nef variants (Y120F and Q125H) associated with a certain HLA class I allele (HLA-B*51:01) inversely correlated with the plasma viral load in treatment-naive HIV-infected patients harboring this HLA allele.

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