literature

HIV mutation literature information.

The interdomain linker region of HIV-1 capsid protein is a critical determinant of proper core assembly and stability.

PMID: 22036671 2011 Virology

Result: 1A), since a P147A mutant was unable to produce virus particles (i.e., RT activity in the supernatant fluid of transfected cells was not detectable).

Activation of p21-activated kinase 2 and its association with Nef are conserved in murine cells but are not sufficient to induce an AIDS-like disease in CD4C/HIV transgenic mice.

PMID: 16407193 2006 The Journal of biological chemistry

Abstract: Among other Tg mice expressing Nef mutants having conserved the Nef-PAK2 association (RD35AA, D174K, P147A/P150A, Delta8-17, and Delta25-65), only Tg mice expressing Nef(Delta8-17) develop kidney and lung diseases, but all showed partial CD4(+) T cell depletion despite some being defective for CD4 down-regulation (RD35AA and D174K).

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