Discussion: Thus, the impact of TAMs need to be better evaluated in coming years since HIV-infected subjects with mutations M184V alone, P119S/T165A/M184V combined or T69 insertion complex, including T210W and T215Y, may have significantly decreased susceptibility to the novel drug Ed4T.
From the chemistry of epoxy-sugar nucleosides to the discovery of anti-HIV agent 4'-ethynylstavudine-Festinavir.
Introduction: Compared with wild type virus, variants with single RT mutations (P119S or T165A) did not show resistance to 4'-ethynylstavudine, however, the M184V and P119S/T165A/M184V strains conferred 3- and 5-fold resistance, respectively.
Introduction: This was puzzling as the P119S and/or T165A have not been observed previously in HIV-1-infected individuals.
Introduction: When the previous HIV resistant strain (P119S/T165A/M184V), with 130-fold resistance to 4'-ethynylstavudine, was recovered by Prof.
Impact of novel human immunodeficiency virus type 1 reverse transcriptase mutations P119S and T165A on 4'-ethynylthymidine analog resistance profile.
PMID: 19704131
2009
Antimicrobial agents and chemotherapy
Abstract: M184V may be the primary resistance-associated mutation of 4'-Ed4T, and P119S and T165A are secondary mutations.
Abstract: Previous in vitro selection for 4'-Ed4T-resistant viral strains revealed M184V and P119S/T165A/M184V mutations on days 26 and 81, respectively; M184V and P119S/T165A/M184V conferred 3- and 130-fold resistance to 4'-Ed4T, respectively.
Abstract: The P119S/M184V and T165A/M184V variants showed about fourfold resistance to 4'-Ed4
Anti-human immunodeficiency virus type 1 activity and resistance profile of 2',3'-didehydro-3'-deoxy-4'-ethynylthymidine in vitro.
PMID: 16048947
2005
Antimicrobial agents and chemotherapy
Abstract: Analysis of 4'-Ed4T-resistant HIV-1 obtained through in vitro selection revealed that the virus was also resistant to 3TC and had two amino acid mutations (P119S and T165A) in addition to the M184V mutation.
In vitro induction of human immunodeficiency virus type 1 variants resistant to 2'-beta-Fluoro-2',3'-dideoxyadenosine.
PMID: 9174190
1997
Antimicrobial agents and chemotherapy
Abstract: Drug sensitivity assays using recombinant infectious clones confirmed that P119S was directly responsible for the reduced sensitivity of HIV-1 to F-ddA.
Abstract: Sequence analyses of the passage 18 virus revealed changes in three amino acids in the reverse transcriptase (RT)-encoding region of the pol gene: P to S at codon 119 (P119S; present in 3 of 13 and 28 of 28 molecular clones before and after F-ddA exposure, respectively), V179D (0 of 13 and 9 of 28, respectively), and L214F (9 of 13 and 28 of 28, respectively).
HIV mutation literature information.
PMID: 
2016
PloS one
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