literature

HIV mutation literature information.

HIV Drug Resistance Surveillance in Honduras after a Decade of Widespread Antiretroviral Therapy.

PMID: 26558396 2015 PloS one

Table: N88S

Outcome of patients on second line antiretroviral therapy under programmatic condition in India.

PMID: 26572102 2015 BMC infectious diseases

Result: Among PI mutations, M46I (n = 5) was the commonest mutation, followed by N88S (n = 3), I50L (n = 2), I84V (n = 2), V 82A (n = 1).

Table: N88S

Discussion: N88S was the second most common PI mutation in our study which is associated with resistance to ATV/r and nelfinavir.

HIV-1 Drug Resistance Mutations: Potential Applications for Point-of-Care Genotypic Resistance Testing.

PMID: 26717411 2015 PloS one

Result: Published reports of aggregated data indicate that I50L and N88S are the main DRMs developing in PI-naive individuals with VF on an ATV- or ATV/r-containing regimen.

Discussion: I50L and N88S are the most commonly occurring major DRMs in PI-naive individuals receiving ATV/r.

Discussion: Our analysis suggests that the four mutations V82A, L76V, I84V, and I47A would have a sensitivity approaching 90% for detecting intermediate or high-level LPV resistance and that I50L and N88S are the most common major PI-associated DRMs to develo

Structural studies on molecular mechanisms of Nelfinavir resistance caused by non-active site mutation V77I in HIV-1 protease.

PMID: 26695135 2015 BMC bioinformatics

Introduction: L23I, D30N, E35G, M46I/L/V, G48V, I54L, G73S/T/C/A, T74S, V82A/F/S/T, I84V, N88D/S and L90M are other mutations correlated to NFV resistance.

Introduction: The other mutations which were co-occurring with DBM and TPM included major mutations like- M46IL, I54MV, I84V, L90M, N88S, V32I,

PMID: 24629078 2014 BMC bioinformatics

Result: We modelled the proteins with unusual mutations (L5F, D29V, L63G, L63R, P79L and T91V), natural polymorphisms (L63H andL63S), and drug-resistant mutant PRs with single mutations or patterns of mutations (D30N, V32I, M36I, M46I, I47V, G48V, I50V, I50L, I54M, Q58E, T74P, L76V, V82A

2014 Update of the drug resistance mutations in HIV-1.

PMID: 25101529 2014 Topics in antiviral medicine

Discussion: Their impacts differ, with I50L, I84V, and N88S having the greatest effect.

Minority drug-resistant HIV-1 variants in treatment naive East-African and Caucasian patients detected by allele-specific real-time PCR.

PMID: 25333961 2014 PloS one

Result: Of these, two had M184V, two had NNRTI mutations (K101E, Y188L) and one had a PI mutation (N88S).

Table: N88S

Extreme multidrug resistant HIV-1 protease with 20 mutations is resistant to novel protease inhibitors with P1'-pyrrolidinone or P2-tris-tetrahydrofuran.

PMID: 23590295 2013 Journal of medicinal chemistry

Result: Also, the PR20 structure does not show the dynamic side chain positions of Asn30 observed in various D30N single and double mutants like D30N/N88D and D30N/N88S.

Persistence of HIV-1 transmitted drug resistance mutations.

PMID: 23904291 2013 The Journal of infectious diseases

Table: N88S

Increasing trends in primary NNRTI resistance among newly HIV-1-diagnosed individuals in Buenos Aires, Argentina.

PMID: 24093951 2013 Journal of the International AIDS Society

Method: Sequences were analyzed to identify mutations associated with reduced susceptibility to protease and RT inhibitors, as reported by the International AIDS Society-USA in 2010: RT-M41L, A62V, K65R, D67N, 69 insert, K70R, L74V,V75I, F77L, L100I, K101P, K103N, V106A, V106M, V108I, Y115F, F116Y,

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