literature

HIV mutation literature information.

Transmission of HIV-1 drug resistance mutations within partner-pairs: A cross-sectional study of a primary HIV infection cohort.

PMID: 29584723 2018 PLoS medicine

Table: N88D

Virological response, HIV-1 drug resistance mutations and genetic diversity among patients on first-line antiretroviral therapy in N'Djamena, Chad: findings from a cross-sectional study.

PMID: 29126456 2017 BMC research notes

Result: Minor mutations found were mainly polymorphisms: K20I/M (21), L10I/V (15), L90W (1), L76S (1), N88D (1), V11I (1), V32L (1) and G48R (1).

Characteristics of Transmitted Drug-Resistant HIV-1 in Recently Infected Treatment-Naive Patients in Japan.

PMID: 26428230 2016 Journal of acquired immune deficiency syndromes (1999)

Abstract: Furthermore, sequences with these mutations, K103N and D30N/N88D formed clusters on phylogenetic trees.

Unique Flap Conformation in an HIV-1 Protease with High-Level Darunavir Resistance.

PMID: 26870021 2016 Frontiers in microbiology

Table: N88D

Q148N, a Novel Integrase Inhibitor Resistance Mutation Associated with Low-Level Reduction in Elvitegravir Susceptibility.

PMID: 27009474 2016 AIDS research and human retroviruses

Introduction: A baseline genotypic resistance test revealed the nucleoside reverse transcriptase inhibitor-resistance mutations L210W and T215D that were interpreted as causing intermediate resistance to zidovudine and low-level resistance to tenofovir; the non-nucleoside reverse transcriptase inhibitor (NNRTI)-resistance mutations K101P and K103S that were interpreted as causing high-level resistance to each of the NNRTIs; and the protease inhibitor-resistance mutations D30N, L33F, I54V, N88D, and L90M

HIV Drug Resistance in Antiretroviral Treatment-Naive Individuals in the Largest Public Hospital in Nicaragua, 2011-2015.

PMID: 27736898 2016 PloS one

Result: Most PI SDRMs were present only as low-abundance variants under the 5% threshold, including L23I, D30N, I47V, I50V, F53L, I54T, G73S, V82A, N83D, I84V, I85V, N88DS, and L90M (Fig 2).

HIV Drug Resistance in Antiretroviral-Naive Patients in Mexico After 10 Years: Is There a Difference?

PMID: 27353350 2016 AIDS research and human retroviruses

Abstract: In both groups, mutations in N88D protease inhibitor were identified, D67N and T69D were found for nucleoside reverse transcriptase inhibitors (NRTIs), and K103N was found for non-nucleoside reverse transcriptase inhibitors.

Assessing transmissibility of HIV-1 drug resistance mutations from treated and from drug-naive individuals.

PMID: 26355575 2015 AIDS (London, England)

Result: Highest transmission ratios were observed for N83D (0.165), N88D/S (0.134) and D30N (0.130) for protease inhibitors; T215Rev (0.727) (for T215Y/F was 0.029) and V75A/M/S/T (0.120) for NRTIs; and K101E/P (0.092) and G190A/E/S (0.091) for NNRTIs (Table 1).

Result: In each class-specific analysis, some SDRMs were classified as outliers: for protease inhibitors, D30N, N88D/S, and L90 M were above; for NRTIs,

Conformational variation of an extreme drug resistant mutant of HIV protease.

PMID: 26397743 2015 Journal of molecular graphics & modelling

Method: Plasmid DNA encoding PR (subtype B of group M) with 20 mutations Q7K; L10F; I13V; I15V; D30N; V32I; L33F; E35D; M36I; S37N; I47V; I54L; Q58E; I62V; L63P; A71V; I84V; N88D; L89T and L90M (termed PR20) cloned between the Nde1 and BamH1 sites

Epidemiological Surveillance of HIV-1 Transmitted Drug Resistance in Spain in 2004-2012: Relevance of Transmission Clusters in the Propagation of Resistance Mutations.

PMID: 26010948 2015 PloS one

Result: It is noteworthy that several major mutations associated to high level resistance to NRTIs (K65R, L74V, Y115F, M184V and T215Y), to NNRTIs (l100I, K101E, K103N/S, V106M, Y181C, Y188L and G190A) and to PIs (D30N, M46I/L, I54V/T, L76V, V82A, I84V, N88D

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