literature

HIV mutation literature information.

Comparison between next-generation and Sanger-based sequencing for the detection of transmitted drug-resistance mutations among recently infected HIV-1 patients in Israel, 2000-2014.

PMID: 28799325 2017 Journal of the International AIDS Society

Table: N83D

HIV-1 Transmitted Drug Resistance Mutations in Newly Diagnosed Antiretroviral-Naive Patients in Turkey.

PMID: 26414663 2016 AIDS research and human retroviruses

Abstract: Nonnucleoside reverse transcriptase inhibitor-associated TDRMs were detected in 3.3% (44/1,306) of patients (L100I, K101E/P, K103N/S, V179F, Y188H/L/M, Y181I/C, and G190A/E/S) and TDRMs to protease inhibitors were detected in 2.3% (30/1,306) of patients (M46L, I50V, I54V, Q58E, L76V, V82A/C/L/T, N83D, I84V, and L90M

HIV Drug Resistance in Antiretroviral Treatment-Naive Individuals in the Largest Public Hospital in Nicaragua, 2011-2015.

PMID: 27736898 2016 PloS one

Result: Most PI SDRMs were present only as low-abundance variants under the 5% threshold, including L23I, D30N, I47V, I50V, F53L, I54T, G73S, V82A, N83D, I84V, I85V, N88DS, and L90M (Fig 2).

HIV Drug Resistance Surveillance in Honduras after a Decade of Widespread Antiretroviral Therapy.

PMID: 26558396 2015 PloS one

Table: N83D

Assessing transmissibility of HIV-1 drug resistance mutations from treated and from drug-naive individuals.

PMID: 26355575 2015 AIDS (London, England)

Result: Highest transmission ratios were observed for N83D (0.165), N88D/S (0.134) and D30N (0.130) for protease inhibitors; T215Rev (0.727) (for T215Y/F was 0.029) and V75A/M/S/T (0.120) for NRTIs; and K101E/P (0.092) and G190A/E/S (0.091) for NNRTIs (Table 1).

Discussion: 0.727 for T215Rev, Table 1); however, precision was low for SDRMs with low prevalence in treatment-failing patients: N83D has a high transmission ratio (0.165) but was only found in one drug-naive and five treatment-failing patients, with large CI.

Epidemiological Surveillance of HIV-1 Transmitted Drug Resistance in Spain in 2004-2012: Relevance of Transmission Clusters in the Propagation of Resistance Mutations.

PMID: 26010948 2015 PloS one

Table: N83D

Transmitted antiretroviral drug resistance mutations in newly diagnosed HIV-1 positive patients in Turkey.

PMID: 25397495 2014 Journal of the International AIDS Society

Abstract: RESULTS: The patients had TDRMs to NRTIs (K65R, M184V), NNRTIs (K101E, K103N/S, G190A/E/S, Y181I/C, Y188H/L) and PIs (M46L, I54V, L76V, V82L/T, N83D, I84V, L90M).

HIV multi-drug resistance at first-line antiretroviral failure and subsequent virological response in Asia.

PMID: 25141905 2014 Journal of the International AIDS Society

Result: Major PI RAMs found in the two patients were M46L, G48V, V82A, N83D and L90M.

Natural polymorphisms and unusual mutations in HIV-1 protease with potential antiretroviral resistance: a bioinformatic analysis.

PMID: 24629078 2014 BMC bioinformatics

Result: We modelled the proteins with unusual mutations (L5F, D29V, L63G, L63R, P79L and T91V), natural polymorphisms (L63H andL63S), and drug-resistant mutant PRs with single mutations or patterns of mutations (D30N, V32I, M36I, M46I, I47V, G48V, I50V, I50L, I54M, Q58E, T74P,

Table: N83D

Increasing trends in primary NNRTI resistance among newly HIV-1-diagnosed individuals in Buenos Aires, Argentina.

PMID: 24093951 2013 Journal of the International AIDS Society

Method: Sequences were analyzed to identify mutations associated with reduced susceptibility to protease and RT inhibitors, as reported by the International AIDS Society-USA in 2010: RT-M41L, A62V, K65R, D67N, 69 insert, K70R, L74V,V75I, F77L, L100I, K101P, K103N, V106A, V106M, V108I, Y115F, F116Y,

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