Abstract: However, this dependency on TRN-SR2 is lost when the HIV N74D capsid mutant is pseudotyped with envelopes mediating pH-dependent endocytosis, such as the VSV-G and Ebola virus envelopes.
Abstract: Remarkably, although somewhat less dependent on TRN-SR2 than wild type virus, the N74D capsid mutant carrying the wild type HIV-1 envelope required TRN-SR2 for efficient replication.
Abstract: We reanalyzed the HIV-1 N74D capsid mutant in cells transiently or stably depleted of transportin-SR2 and confirm that the N74D capsid mutant is independent of TRN-SR2 when pseudotyped with the vesicular stomat
Discussion: A more distantly related lentivirus, FIV, behaved remarkably similar to N74D HIV-1 in infection assays.
Discussion: Because N74D mutation of HIV-1 CA enhanced rhTRIM5alpha binding, it is conceivable that TRIM5alpha in vivo additionally counterselects an N74D core in primate lentiviruses.
Discussion: Dependence on NUP155 expression correlated with resistance to mCPSF6-358, raising the possibility that this factor directly interacts with N74D HIV-1 or FIV PICs.
Discussion: Experiments with N74D HIV-1 indicate that TNPO3 is not required for nuclear entry.
Discussion: In contrast, infection by the N74D mutant was less dependent on TNPO3, RANBP2, or NUP153, suggesting that these proteins interacted, directly or indir
HIV mutation literature information.
PMID: 
2011
Retrovirology
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