Analysis of HIV type 1 gp41 and enfuvirtide susceptibility among men in the United States who were HIV infected prior to availability of HIV entry inhibitors.
PMID: 19552592
2009
AIDS research and human retroviruses
Introduction: Five samples with E137K and one sample with S138A also had N42S; one sample with E137K also had N42S and L44M.
Introduction: The N42S polymorphism was detected in 28 (16%) of the 175 samples, including two samples that also had L44M, one of which also had E137K (see below
Introduction: We also detected the N42S hypersusceptibility mutation in 28 (16%) of the 175 samples; this is similar to the rate of detection of N42S in other cohorts of ENF-naive individuals with subtype B HIV infection.
Table: N42S
Natural resistance-associated mutations to Enfuvirtide (T20) and polymorphisms in the gp41 region of different HIV-1 genetic forms from T20 naive patients.
Abstract: Different substitutions were related to subtypes: N42S in subtypes A, B, G and C, but not in F, Q56R in subtype A from CRF02_AG, and L54M in subtype B from CRF14_BG.
Enfuvirtide binding domain is highly conserved in non-B HIV type 1 strains from Cameroon, West Central Africa.
PMID: 15929708
2005
AIDS research and human retroviruses
Abstract: The N42S polymorphism was present in 148 (80.4%) strains.
Characterization of determinants of genotypic and phenotypic resistance to enfuvirtide in baseline and on-treatment HIV-1 isolates.
Abstract: RESULTS: HIV-1 gp41 aa 36-45 were highly conserved in virus from ENF-naive patients, except for a 15% incidence of N42S which did not reduce sensitivity to ENF.
HIV mutation literature information.
PMID: 
2009
AIDS research and human retroviruses
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