literature

HIV mutation literature information.

HIV-1 clade C escapes broadly neutralizing autologous antibodies with N332 glycan specificity by distinct mechanisms.

PMID: 27576440 2016 Retrovirology

Introduction: As shown in Table 4, knocking out of these glycan residues was found to be correlated significantly with increased susceptibility of the NLR-2007.J12 Env (N139A/N142A/N145gA, N145lA/N147A) with longer V1 loop to PGT121 and PGT128 mAbs by >20 and >35 folds respectively.

Introduction: However, only 1.9-fold increase in neutralization of NLR-2007.J12 (N139A/N142A/N145gA, N145lA/N147A) to autologous plasma antibodies was observed.

Heat shock protein 90AB1 and hyperthermia rescue infectivity of HIV with defective cores.

PMID: 23200770 2013 Virology

8Discussion: In this view maturation destabilizes the virus core, facilitating its dissociation in the newly infected cell and perhaps facilitating reverse transcription of the genome."" The transdominant effects of cell activation, HSP90AB1 expression, and increased temperature independently rescued the CA-mutant viruses, and further analysis of the

Result: N139A appeared to most benefit from cellular expression of HSP90AB1 and exhibited exponential growth with the potential to establish a spreading infection.

Result: The N139A mutation in CA displays a normal WT-like stable core and normal core numbers per virion with no discernable defects in assembly, maturation, or viral RNA packaging, yet this mutation impairs HIV infectivity.

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