Result: Most of the recombinant plasmids constructed from sequences obtained during ENF treatment carried the V38A mutation as the only change associated with ENF resistance, although four clones derived from the 140N patient carried the N42T mutation, and three others showed the N126K mutation.
[Analysis of the polymorphism of the genome region of HIV-1 encoding the fusion protein].
Result: All intermediate and late Env clones (weeks 59 and 94) carried the N43D mutation with the N126K substitution, although in contrast to patient C, phenotypic resistance levels did not increase further under prolonged treatment.
Result: In contrast, the N126K compensatory mutation in patient D viruses was detected exclusively in on-treatment viral sequences, pointing to it as a presumed contributor to the parallel infectivity gains of HR1-HR2 and full Env recombinants.
Result: Other mutations included substitutions N125D (patients A, B and C), N125S and N126K (patient D) and E137K (patient E) (Table S1).
Result: Taken together, our data suggest that both
In vitro selection and characterization of HIV-1 variants with increased resistance to sifuvirtide, a novel HIV-1 fusion inhibitor.
PMID: 21098485
2011
The Journal of biological chemistry
Abstract: A downstream substitution at position 126 (N126K) in the C-terminal heptad repeat region was also found.
Characterization of HIV-1 resistance to a fusion inhibitor, N36, derived from the gp41 amino-terminal heptad repeat.
Abstract: Among these substitutions, N126K and/or E137Q conferred resistance to not only N36, but also C34, which is the corresponding C-HR-derived peptide fusion inhibitor.
Abstract: Denaturing experiments revealed that the stability of the 6-helix bundle of N126K/E137Q is greater than in the wild-type.
Abstract: The structure of the 6-helix bundle with N126K/E137Q was identical to that in wild-type HIV-1 except for the presence of a new hydrogen bond.
Abstract: These results suggest that the stabilizing effect of N126K/E137Q provides resistance to N36 and C34.
Abstract: This HIV-1 acquired a total of four amino acid substitutions, D36G, PMID: 19552592
2009
AIDS research and human retroviruses
Introduction: Polymorphisms in the HR2 region (e.g., N126K, E137K, and S138A) may increase the fitness of HIV-1 viruses that have ENF resistance mutations in HR1.
Introduction: The mutations analyzed included (1) mutations in HR1 that are associated with a >10-fold reduction in most clinical isolates and site-directed mutants (major mutations: G36D/E, V38A/E, Q40H, and N43D), (2) other ENF resistance mutations in HR1 (G36S/V, I37V, V38G/M, N42T, N43K, L44M, and L45M), (3) N42S, a natural poly
Human immunodeficiency virus type 1 gp 41 mutations in proviral DNA among antiretroviral treatment-naive individuals from India.
PMID: 19400735
2009
AIDS research and human retroviruses
Abstract: In subtype B-infected individuals, the various HR1 region substitutions in env gp41 that have been associated with ENF resistance include A30V, L33S/T/V, L34M, G36D/E/S/V, I37T/K/V, V38A/M/E/G, Q39R, Q40H, N42T/D, N43D/K/S, L44M, L45M, R46M, L54M, and Q56K/R as well as N126K and
Design of peptide-based inhibitors for human immunodeficiency virus type 1 strains resistant to T-20.
PMID: 19073606
2009
The Journal of biological chemistry
Abstract: In this case, we designed a variant of C34 with the secondary escape mutation N126K and showed that it can effectively inhibit replication of C34-resistant HIV-1.
The application of perfluorooctanoate to investigate trimerization of the human immunodeficiency virus-1 gp41 ectodomain by electrophoresis.
Abstract: In addition, the proteins expressed from the two mutants in the heptad repeat (HR) domains of gp41, I62P, and N126K, were also examined by the PFO-PAGE analysis for functional ramification of molecular organization.
Abstract: Remarkably, the I62P mutation completely abolished the gp41 trimer formation, whereas the N126K mutation resulted in a more stable trimer.
Evolution of genotypic and phenotypic resistance during chronic treatment with the fusion inhibitor T-1249.
PMID: 18184079
2007
AIDS research and human retroviruses
Abstract: A novel substitution, A50V (n = 12, 32%), was also common, as were the N126K and S138A substitutions in heptad-repeat 2 (HR-2).
HIV mutation literature information.
PMID: 
2012
Retrovirology
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