literature

HIV mutation literature information.

Conformational variation of an extreme drug resistant mutant of HIV protease.

PMID: 26397743 2015 Journal of molecular graphics & modelling

Introduction: Recently; for example; the effects of single mutations V32I and M46L were studied by molecular dynamics in.

The Evolving Genotypic Profile of HIV-1 Mutations Related to Antiretroviral Treatment in the North Region of Brazil.

PMID: 26543866 2015 BioMed research international

Abstract: Most common protease mutations were M46I, V82A, I54V, L90M, I84V, M46L, and L76V.

Discussion: In PR, mutations M46I/L, I54V, L76V, V82A, I84V, and L90M were associated with PI/r resistance in multifailed patients.

Discussion: On the other hand, in multifailed individuals, seven major PI mutations associated with resistance were documented: M46I,

HIV Drug Resistance Surveillance in Honduras after a Decade of Widespread Antiretroviral Therapy.

PMID: 26558396 2015 PloS one

Result: Only M46IL was more frequent in recently infected individuals (p = 0.0240, Fig 2).

Result: The first case included a virus with acquired K103N from a heterosexual male enrolled at Tegucigalpa and a female with transmitted K103N from San Pedro Sula (Fig 1B); the second case included two females enrolled at San Pedro Sula, one with acquired K103N and the other with transmitted K103N (Fig 1C); and the third case included two closely related, multidrug resistant viruses from heterosexual males enrolled at La Ceiba, one containing acquired M46L and T215Y and the other containing transmitted M46 and T215S (Fig 1D).

Result: The most prevalent PDR mutations were M46IL<

Structural studies on molecular mechanisms of Nelfinavir resistance caused by non-active site mutation V77I in HIV-1 protease.

PMID: 26695135 2015 BMC bioinformatics

Introduction: L23I, D30N, E35G, M46I/L/V, G48V, I54L, G73S/T/C/A, T74S, V82A/F/S/T, I84V, N88D/S and L90M are other mutations correlated to NFV resistance.

Introduction: The other mutations which were co-occurring with DBM and TPM included major mutations like- M46IL, I54MV, I84V, L90M, N88S, V32I,

PMID: 29124158 2015 Biochemistry and biophysics reports

Method: MDR769 L33F is based on the previously studied multi-drug resistant variant 769, MDR769, which contains the mutations Q7K, L10I, M36V, M46L, I54V, I62V, L63P, A71V, V82T, I84V, L90M.

Characteristics of HIV-1 natural drug resistance-associated mutations in former paid blood donors in Henan Province, China.

PMID: 24586665 2014 PloS one

Discussion: Results from the HIV-1 drug resistance mutation research by the International AIDS Society-USA (updated in March 2013) have revealed that PI resistance mutation sites are L10I, K20M, V32I, M36I, M46I/L, I47V/A, I50V, Q58E, A71V, G73S, V82A/F/T, I84V, L89V,L90M; NRTIs resistance mutations are M41L, A62V,

PMID: 24738918 2014 ACS chemical biology

Method: The PRP51 construct contains 14 mutations (L10I, I15V, K20R, L24I, V32I, L33F, M36I, M46L, I54M, L63P, K70Q, V82I, I84V, and L89M) plus three other mutations Q7K to minimize autoproteolysis and C67A and C95A to prevent cysteine-induced aggregation.

Result: Four mutations associated with drug resistance, V32I,

PMID: 25003939 2014 PloS one

Result: In the protease gene, three subjects (7%) had major mutations at position 46 (M46I/L) associated with PR drug resistance mutations (Table 3).

Table: M46L

Discussion: Since PIs were not used in Tanzania at the time that the samples were collected, the mutations M46I and M46L most likely represent natural polymorphisms rather than transmitted drug-resistant strains.

A multi-drug resistant HIV-1 protease is resistant to the dimerization inhibitory activity of TLF-PafF.

PMID: 25108107 2014 Journal of molecular graphics & modelling

Introduction: The multidrug-resistant (MDR)-769 HIV-1 protease consists of amino acid substitutions: L10I, M36V, M46L, I54V, I62V, L63P, A71V, V82A, I84V and L90M.

HIV multi-drug resistance at first-line antiretroviral failure and subsequent virological response in Asia.

PMID: 25141905 2014 Journal of the International AIDS Society

Result: Major PI RAMs found in the two patients were M46L, G48V, V82A, N83D and L90M.

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