Prevalence and determinants of virological failure, genetic diversity and drug resistance among people living with HIV in a minority area in China: a population-based study.
Result: The most common mutations in NNRTIs were K103N/KN (64.69%), V179D/E (23.47%) and Y181C/YC/I (14.00%), they were M184V/MV/I (36.29%), T215F/FS/TNSY (7.50%) and K219Q (5.92%) in NRTIs, and they were Q58E/QE (4.93%), L10F/LFI (0.39%) and M46L (0.39%) in PIs.
Pretreatment resistance mutations and treatment outcomes in adults living with HIV-1: a cohort study in urban Malawi.
In vivo drug resistance mutation dynamics from the early to chronic stage of infection in antiretroviral-therapy-naive HIV-infected men who have sex with men.
Abstract: Four individuals exhibited additional DRMs (M46I/L; I47A; I54M, L100V) as HIV minority populations (abundance, 2-20%) that emerged during the chronic stage but ephemerally.
The genotype distribution, infection stage and drug resistance mutation profile of human immunodeficiency virus-1 among the infected blood donors from five Chinese blood centers, 2014-2017.
Abstract: 48 DRMs were identified from 43 samples, indicating a drug resistance prevalence of 12.1% (43/356), which include seven protease inhibitors (PIs) accessory DRMs (Q58E, L23I and I84M), two PIs major DRMs (M46I, M46L), seven nucleoside Result: 3) Nine protease inhibitor (PIs) DRMs were observed including, seven PIs accessory DRMs: Q58E (n = 5), L23I (n = 1), I84M (n = 1) and two PIs major DRM: M46L (n = 2).
Diversity of HIV-1 genotypes and high prevalence of pretreatment drug resistance in newly diagnosed HIV-infected patients in Shanghai, China.
Result: PI resistance were detected in only two samples, being simultaneously resistant to ATV/r and LPV/r at a potential low level caused by M46I/L mutation.
Trends in the Molecular Epidemiology and Genetic Mechanisms of Transmitted Human Immunodeficiency Virus Type 1 Drug Resistance in a Large US Clinic Population.
Result: A Kaplan-Meier analysis could be performed for 18 TDRMs (K20T, L23I, K43T, M46I/L/V, I54V, M41L, L74I, M184V, L210W, K2
Discussion: In concordance with the three other studies on the persistence of TDRMs, for most PI mutations (I54V, K43T, L23I, M46I/L/V) a long mean survival time between 2.2 and 4.2 years was found in our study cohort, with the exception of K20T that had a mean survival time of one (95% CI 0.4-1.2) year.
Result: A shift of 0.8 A in M46L is observed in PRS17/CA-p2 in comparison to complex with DRV.
Result: Also, PR with individual mutations of M46L, G48V, and I54V in the flaps showed worse inhibition constants (Ki) for DRV and saquinavir relative to the wild-type PR.
Result: Flap mutations M46L, G48V, and I54V in PRS17 are implicated in the curling of flaps observed in the inhibitor-free structure.
Result: However, G48V together with M46L also alters the conformation of other flap residues
Characterisation of protease resistance mutations in a South African paediatric cohort with virological failure, 2011 - 2017.
HIV mutation literature information.
PMID: 
2020
BMC infectious diseases
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