literature

HIV mutation literature information.

Ultra-deep sequencing improves the detection of drug resistance in cellular DNA from HIV-infected patients on ART with suppressed viraemia.

PMID: 30137335 2018 The Journal of antimicrobial chemotherapy

Abstract: However, the detection of RAMs by UDS with a 1% cut-off was significantly higher than that of bulk sequencing for RT codons D67N (65.4% versus 52.3%), M184V (66.2% versus 52.3%), L210W (48.9% versus 36.4%) and T215Y (57.9% versus 42.1%) and PR codons M46I (46% versus 26%), I54L (12.4% versus 3.9%), V82A (44.5% versus 29.9%) and L90M (57.7% versus 42.5%).

HIV Reverse Transcriptase and Protease Genes Variability Can Be a Biomarker Associated with HIV and Hepatitis B or C Coinfection.

PMID: 29844604 2018 Scientific reports

Result: The major mutations to PI were I54V (2.9%), V82A (11.7%), M46I (8.8%) and L90M (40.4%).

High level of HIV-1 drug resistance mutations in patients with unsuppressed viral loads in rural northern South Africa.

PMID: 28750647 2017 AIDS research and therapy

Result: Two (3.0%) subjects harbored major PI DRM (D30N, M46I and V32I).

Enhanced surveillance of HIV-1 drug resistance in recently infected MSM in the UK.

PMID: 27742812 2017 The Journal of antimicrobial chemotherapy

Abstract: The most common mutations detected at >20% and 2%-20% mutation frequency differed for each drug class, these respectively being: L90M (n = 7) and M46IL (n = 10) for PIs; T215rev (n = 9) and D67GN (n = 4) for NRTIs; and K103N (n = 5) and G190E (n = 2) for NNRTIs.

Surveillance of Transmitted Drug Resistance in HIV-1-Infected Youths Aged 16 to 25 Years, a Decade After Scale-up of Antiretroviral Therapy in Hebei, China.

PMID: 27750023 2017 AIDS research and human retroviruses

Abstract: All TDR mutations (M46L/I, Y181C, K101E, and G190E) were found only in youths infected with HIV-1 through sexual activity.

Abstract: TDR mutations resided in CRF01_AE (M46I/L and G190E) and subtype B (Y181C and K101E).

Low Rates of Transmitted Drug Resistance Among Newly Identified HIV-1 Seroconverters in Rural Rakai, Uganda.

PMID: 27798967 2017 AIDS research and human retroviruses

Abstract: Two individuals had a single non-nucleoside reverse transcriptase inhibitor mutation each, K101E and K103N, and one had a single protease inhibitor mutation, M46I.

Surveillance of HIV-1 pol transmitted drug resistance in acutely and recently infected antiretroviral drug-naive persons in rural western Kenya.

PMID: 28178281 2017 PloS one

Abstract: Predominant TDR mutations in the reverse transcriptase included K103N/S (4.6%) and M184V (2.3%); only M46I/L (1.1%) occurred in the protease.

Result: The dominant TDRMs in the RT gene were K103N/S (n = 4, 4.6%) and M184V (n = 2, 2.3%), while in the PR gene only M46I/L (n = 1, 1.1%) occurred.

The infection staging and profile of genotypic distribution and drug resistance mutation among the human immunodeficiency virus-1 infected blood donors from five Chinese blood centers, 2012-2014.

PMID: 28622345 2017 PloS one

Result: 2) Six protease inhibitors (PIs) DRMs were observed including, four PIs accessory DRMs: L23I (n = 1), K43T (n = 1) and Q58E (n = 2); and two PIs major DRMs: M46I.

Result: For example, 16 of 27 donors showed PLLR (or above) to NNRTI due to V179D/E mutations; three donors with mutations of E138A were found to have PLLR to etravirine (ETR) and low-level resistance (LLR) to rilpivirine (RPV); specimen CQ12003214 was identified to have PLLR to five PIs and intermediate resistance (IR) to nelfinavir (NFV) caused by PI major DRM o

Comparison between next-generation and Sanger-based sequencing for the detection of transmitted drug-resistance mutations among recently infected HIV-1 patients in Israel, 2000-2014.

PMID: 28799325 2017 Journal of the International AIDS Society

Result: M46I/L, potentially conferring low-level resistance to any PI, was the only mutation found in 5% (4/80) of the patients.

Result: Some of the low-frequency TDRMs identified are consistent with APOBEC-mediated G-to-A editing: the PI M46L/I and D30N, the NRTI D67N and the NNRTI G190E TDRM, as well as the E138K amino substitution, were all related to APOBEC.

Table: M46I

Virological response, HIV-1 drug resistance mutations and genetic diversity among patients on first-line antiretroviral therapy in N'Djamena, Chad: findings from a cross-sectional study.

PMID: 29126456 2017 BMC research notes

Abstract: Overall, 32% (37/116) patients presented >= one major drug resistant mutation(s), with 29% (34/116) to nucleos(t)ide reverse transcriptase inhibitors (67% [29/43] M184V/I, 30% [13/43] T215Y/F, 19% [8/43] V75A/F/I/L/M, 9% [4/43] K70P/R/W, 9% [4/43] K219E/N/Q and 5% [2/43] A62V); 86% (37/43) to non-nulceos(t)ide reverse transcriptase inhibitors (30% [13/43] K103N/S/E, 26% [11/43] Y181C/V/F/L, 2% [1/43] L100I, 2% [1/43] F227L, 2% [1/43] P225H); and 2% (1/43

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