Result: For PIs, the most frequent ADR-CRM were M46IL (3.6%), V82AT (3.2%), L90M (2.6%) and Q58E (2.1%) and, the only SDRM observed was M46L/I (1.5%) (Fig 1C).
Result: Mutations associated with PIs were more observed at position M46IL and V82A in subjects on second-line and rescue schemes (Fig 3D and 3E).
Discussion: Our mutation pattern analyses showed that the most frequent SDRM were: K103N (4.0%) and P225H (2.0%) for NNRTIs, T215 revertants (2.4%) and M41L (2.0%) for NRTIs
Evolutionary Dynamics and Complicated Genetic Transmission Network Patterns of HIV-1 CRF01_AE among MSM in Shanghai, China.
Result: Only one individual harbored three mutations including M46I, A62V and T69N.
Single Genome Analysis for the Detection of Linked Multiclass Drug Resistance Mutations in HIV-1-Infected Children After Failure of Protease Inhibitor-Based First-Line Therapy.
PMID: 25923117
2015
Journal of acquired immune deficiency syndromes (1999)
Abstract: In one child, the majority species contained M184V in reverse transcriptase linked to L10F, M46I/L, I54V, and V82A in PR and a triple-class drug-resistant variant with these mutations linked to the NNRTI mutation V108I.
Result: D had virological failure at week 40 (with the PI mutation M46I in 1 of 38 single genomes) but achieved a viral load less than 400 copies per milliliter by week 96 of early ART that was maintained until the end of the CHER trial.
Result: Despite the high frequency of M46I, it was also not detected by bulk sequence analysis.
Result: The variant contained
The Evolving Genotypic Profile of HIV-1 Mutations Related to Antiretroviral Treatment in the North Region of Brazil.
Abstract: The most frequent TDR mutations were M46I (2) in the Result: Two TDR mutations, M46I (2) and I50V (1) were found in the protease region, and the other eight TDR mutations, K65E(1), D67N(1), T69N(1), K103N(1), Y181C(2), G190E(1), L210W(1), and P225H(1) were from the reverse transcriptase fragment.
Discussion: The most common TDR mutations were M46I in PR and Y181C in RT.
Global HIV-1 transmitted drug resistance in the INSIGHT Strategic Timing of AntiRetroviral Treatment (START) trial.
Abstract: The most frequent TDR mutations observed were M41L, D67N/G/E, T215F/Y/I/S/C/D/E/V/N, 219Q/E/N/R, K103N/S, and G190A/S/E in reverse transcriptase, and M46I/L and L90M in protease.
Discussion: Overall, transmitted protease resistance mutations were identified less frequently, with M46IL and L90M being the most common.
Discussion: The M46IL is considered a primary mutation for indinavir, but is also a common secondary mutation associated
[HIV-1 subtype diversity and transmission clusters among men having sex with men who recently got HIV-l infection, in Zhejiang province].
PMID: 25876868
2015
Zhonghua liu xing bing xue za zhi
Abstract: Three surveillance drug resistance mutations (M46I, T215S and G190A) were found in three samples (each sample harbored only one resistance mutation).
Characterization of HIV drug resistance mutations among patients failing first-line antiretroviral therapy from a tertiary referral center in Lusaka, Zambia.
Abstract: Three patients (5%) had major protease inhibitor (PI) resistance mutations: all three had the V82A mutation, and one patient (Clade J virus) had a concurrent M46I, Q58E, and L76V DRM.
Result: V82A was detected in all three patients, with concurrent M46I, Q58E, and L76V in one of the three patients harboring the clade J HIV-1 virus.
HIV mutation literature information.
PMID: 
2016
PloS one
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