Abstract: Analysis of mutational effects in the human immunodeficiency virus type-1 (HIV-1) provirus has revealed that as few as four amino acid side-chain substitutions in the HIV-1
protease (
M46I/
L63P/
V82T/
I84V) suffice to yield viral variants cross-resistant to a panel of
protease inhibitors either in or being considered for clinical trials (Condra, J.
Abstract: The role of the
M46I and
L63P substitutions in drug resistance is not obvious from the crystallographic data, but they induce conformational perturbations (0.9-1.1 A) in the flap domain of the native enzyme and may affect the stability and/or activity of the enzyme unrelated directly to binding.
HIV mutation literature information.
PMID: 
1995
The Journal of biological chemistry
Browser Board
Co-occurred Entities
Filtrator