literature

HIV mutation literature information.

Drug resistance-associated genotypic alterations in the pol gene of HIV type 1 isolates in ART-naive individuals in North India.

PMID: 18240959 2008 AIDS research and human retroviruses

1Abstract: In the protease region it showed a major drug resistance mutation at M46I as well as ""minor"" positions F53L and T74P."

The HIV-1 protease substitution K55R: a protease-inhibitor-associated substitution involved in restoring viral replication.

PMID: 18252693 2008 The Journal of antimicrobial chemotherapy

Abstract: RESULTS: The K55R mutation, which is not a natural polymorphism, was identified to be strongly associated with protease mutations M46I/L and to a lesser extent L24I, I54V and V82A/T/S/F.

Trend of drug-resistant HIV type 1 emergence among therapy-naive patients in Nagoya, Japan: an 8-year surveillance from 1999 to 2006.

PMID: 18275342 2008 AIDS research and human retroviruses

Abstract: The 402 viruses were phylogenetically analyzed, revealing three independent clusters comprising PI-resistant variants with the M46I or L90M mutation, NNRTI-resistant variants with the K103N mutation, and 215-revertant variants.

HIV type 1 pol gene diversity and antiretroviral drug resistance mutations in Santos, Brazil.

PMID: 18327988 2008 AIDS research and human retroviruses

Abstract: Drug resistance mutations identified in common to subtypes B, F, and recombinants B/F were protease inhibitors M46I/L (29%), I54V (24%), A71V (22%), and V82A/F (31%); reverse transcriptase nucleoside resistance mutations M41L (52%), D67N (30%), K70R (26%), M184V (88%), L210W (29%), T215Y/I/F (65%), and K219Q/E/N (28%); and reverse transcriptase nonnucleoside resistance mutation K103N (52%).

Impact on replicative fitness of the G48E substitution in the protease of HIV-1: an in vitro and in silico evaluation.

PMID: 18545158 2008 Journal of acquired immune deficiency syndromes (1999)

Abstract: These simulations documented that the G48E mutant interacted with PI resistance mutations (M46I, I54V, Q58E, and L63P) and with natural polymorphisms specific to subtype A1 (E35D, M36I, and R57K) that were present in the patient's virus.

Analysis of near full-length genomic sequences of drug-resistant HIV-1 spreading among therapy-naive individuals in Nagoya, Japan: amino acid mutations associated with viral replication activity.

PMID: 18620491 2008 AIDS research and human retroviruses

Abstract: Genomes comprised seven protease inhibitor (PI)-resistant viruses possessing an M46I (n = 6) or L90M mutation (n = 1) and five non-nucleoside reverse transcriptase inhibitor-resistant viruses possessing a K103N mutation.

HIV drug resistance pattern among HAART-exposed patients with suboptimal virological response in Ouagadougou, Burkina Faso.

PMID: 18667925 2008 Journal of acquired immune deficiency syndromes (1999)

Abstract: Dominant mutations included M46I (37%), 154V (26%), V82A/T/F (30%) in PR; K103N (44%), G190A/S (16%) and T215F/Y (48%) (NRTIs) in RT.

Genotypic resistance analysis of the virological response to fosamprenavir-ritonavir in protease inhibitor-experienced patients in CONTEXT and TRIAD clinical trials.

PMID: 18852278 2008 Antimicrobial agents and chemotherapy

Abstract: The JT procedure led to selecting the CONTEXT/TRIAD genotypic set of mutations, I15V, M46I/L, I54L/M/V, D60E, L63P/T, and I84V, as providing the strongest association with the VR (P = 1.45 x 10(-11)).

HIV type 1 subtype C drug resistance among pediatric and adult South African patients failing antiretroviral therapy.

PMID: 19000027 2008 AIDS research and human retroviruses

Abstract: Of the patients who received PIs, the most common mutations were V82A/T (12%), M46I (11%), and L90M (8%).

Short communication: Different mutation patterns in subtype CRF06_cpx after mother-to-child transmission.

PMID: 19032066 2008 AIDS research and human retroviruses

Abstract: GRT during follow-up showed selection of L74V/K103N/M184V/M230L in RT and M46I/H63Q/N88S in PR.

Browser Board

Co-occurred Entities

Filtrator