Abstract: M46I and I47V were the most common mutations for PIs, M184V was the most common mutation for the NRTIs, and K103N/S was the most common mutation for NNRTIs.
Result: The most common mutations were M46I and I47V for PIs, M184V for NRTIs, and K103N/S for NNRTIs (Table 6).
Table: M46I
Discussion: M46I and I47V were the most frequent mutations for PMID: 32183889
2020
Virology journal
Result: The major mutations were I54L (3.83%), V82L (2.84%) and M46I/L (1.53%).
Table: M46I/L
Drug Resistance Mutations Against Protease, Reverse Transcriptase and Integrase Inhibitors in People Living With HIV-1 Receiving Boosted Protease Inhibitors in South Africa.
Result: The most common major PI RAMs observed were M46I and V82A (n = 12; 12%); I54V (n = 10; 10%); I84V and L76V (n = 7; 7%); I47A/V (n = 3; 3%); I50L/V (n = 2; 2%); and V32I (n = 2; 2%) (Table 1).
Discussion: Furthermore, these findings are in agreement with that observed both V82A and M46I has the most common mutation in infected children receiving PI-based cART.
Discussion: Our findings also showed M46I and V82A RAMs as the most prevalent major PI RAMs.|
Polymorphisms and drug resistance analysis of HIV-1 isolates from patients on first line antiretroviral therapy (ART) in South-eastern Nigeria.
Discussion: M46I/L is a nonpolymorphic PI-selected mutation that reduces susceptibility to indinavir (IDV), nelfinavir (NFV), fosamprenavir (FPV), lopinavir (LPV) and atazanavir (ATV) when present with other mutations.
In vivo drug resistance mutation dynamics from the early to chronic stage of infection in antiretroviral-therapy-naive HIV-infected men who have sex with men.
Abstract: Four individuals exhibited additional DRMs (M46I/L; I47A; I54M, L100V) as HIV minority populations (abundance, 2-20%) that emerged during the chronic stage but ephemerally.
Genotyping and antiretroviral drug resistance of human immunodeficiency Virus-1 in Jazan, Saudi Arabia.
Discussion: These results are inconsistent with the previous study of Jamjoom et al, who reported that the most prevalent PI mutations were I54 V, L90 M, V82A, M46I, I50 V, and D30N.
Differences in human immunodeficiency virus-1C viral load and drug resistance mutation between plasma and cerebrospinal fluid in patients with human immunodeficiency virus-associated cryptococcal meningitis in Botswana.
Abstract: HIV-1 DRM discordance was found in 3/26 (11.5%); 1 had I84IT and another had M46MI in CSF only.
Result: Of these, one had HIV-1 strain harbouring I84IT and the other had M46MI protease inhibitor (PI)-associated mutation in CSF but not in the plasma.
Discussion: Although there is discordance in these mutations between the CSF and plasma, according to the Stanford HIV drug resistance database, M46MI only confers resistance PI only when present with other mutation while I84T is not known to produce resistance to PI.
Discussion: One participant had M46MI m
Virologic suppression in patients with a documented M184V/I mutation based on the number of active agents in the antiretroviral regimen.
Result: Only M46I mutation was found in both samples.
Table: M46I
Prevalence and determinants of virological failure, genetic diversity and drug resistance among people living with HIV in a minority area in China: a population-based study.
ViMRT
HIV mutation literature information.
PMID: 
2020
PloS one
