literature

HIV mutation literature information.

Nationwide Study of Drug Resistance Mutations in HIV-1 Infected Individuals under Antiretroviral Therapy in Brazil.

PMID: 34069929 2021 International journal of molecular sciences

Result: SDRM in PR were found in 5021 (24.82%) sequences and the more frequent were V82A (9.99%, n = 2021), M46I (9.58%, n = 1938), and I54V (8.50%, n = 1719).

Result: The SDRM with most similar prevalence when comparing both groups were M46I, V82A, L90M and I54V.

Reverse transcriptase and protease inhibitors mutational viral load in HIV infected pregnant women with transmitted drug resistance in Argentina.

PMID: 34085506 2021 Revista espanola de quimioterapia

Abstract: Most frequent PI-RAMs were I85V, M46I, I50V and L90M (n=2, 5% each).

Result: Most frequent PI-RAMS were I85V, M46I, I50V and L90M (n=2, 5% each), all of them with modest impact in the activity of currently available PIs.

Feasibility and clinical relevance of HIV-1 drug resistance testing in patients with low-level viraemia in South Africa.

PMID: 34278422 2021 The Journal of antimicrobial chemotherapy

Abstract: Major PI mutations, including M46I and V82A, were detected in 7.2% (9/125) of patients.

Correlation of HIV-1 drug resistant mutations and virologic failure.

PMID: 34584606 2021 The Pan African medical journal

Introduction: These mutations included M184V, K65R,D67N,K70R,K219Q,Q151M, T215F, M41L, T69N, V75M, M41L, T69N, V75M, D67G, V75M, M184I, T215N, M41LM, T215N, K219N,210W, T215Y as NRTIs

Table: M46I

Characterizing HIV-1 Genetic Subtypes and Drug Resistance Mutations among Children, Adolescents and Pregnant Women in Sierra Leone.

PMID: 34573296 2021 Genes

Result: We observed 4 PI-associated RAMs in 6 children/adolescents, as follows: the combination mutation I54V + V82A (n = 2), M46I/M (n = 1), and I84I/V (n = 1).

Transmitted drug resistance and transmission clusters among HIV-1 treatment-naive patients in Guangdong, China: a cross-sectional study.

PMID: 34488793 2021 Virology journal

Discussion: The most frequent PI-associated mutation in our study was M46L, whereas it is Q56E in southwest China, M46I in Iceland, and L90M in the south-central United States.

HIV-1 Drug Resistance and Genetic Transmission Networks Among MSM Failing Antiretroviral Therapy in South China 2014-2019.

PMID: 34377002 2021 Infection and drug resistance

Result: One case (0.3%, 1/393) carried PI-related DRMs, K20T, M46I, and K43T.

Table: M46I

Understanding the co-evolutionary molecular mechanisms of resistance in the HIV-1 Gag and protease.

PMID: 34253143 2021 Journal of biomolecular structure & dynamics

Abstract: Here we showed that distinct changes in PR's active site, flap and elbow regions due to several PR resistance mutations (L10F, M46I, I54V, L76V, V82A) were found to alter LPV and DRV drug binding.

High Detection Rate of HIV Drug Resistance Mutations among Patients Who Fail Combined Antiretroviral Therapy in Manaus, Brazil.

PMID: 34212033 2021 BioMed research international

Result: Only half of the individuals had used PI (n = 46/82), only 17% of individuals presented DRMs associated with protease inhibitors (n = 14), and the most frequent mutations were V82A/L/M (6/82; 7.3%) and I54L/M/V (5/82; 6%), L90M (4/82; 4.8%), and M46L/I (4/82; 4.8%) (Figure 1).

Prevalence of transmitted HIV-1 drug resistance among treatment-naive individuals in China, 2000-2016.

PMID: 34195923 2021 Archives of virology

Abstract: The most frequent mutation was M46L (58, 0.89%), followed by K103N (36, 0.55%), M46I (36, 0.55%), and M184V (26, 0.40%).

Abstract: While most TDR mutations were associated with reduced relative transmission fitness, mutation M46I was associated with higher relative transmission fitness than the wild-type strain.

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