Abstract: NRTI susceptibility was not affected by the addition of H208Y in phenotypic assays carried out in MT-4 cells using recombinant HIV-1 containing wild-type (subtype B, BH10), H208Y, M41L/L210W/T215Y or M41L/H208Y/L21
Abstract: However, enzymatic studies carried out with purified RTs revealed that in the presence of M41L/L210W/T215Y, H208Y increases the RT's ability to unblock and extend primers terminated with zidovudine, tenofovir and in a lesser extent, stavudine.
HIV-1 drug resistance in the iPrEx preexposure prophylaxis trial.
PMID: 24740633
2014
The Journal of infectious diseases
Result: Viruses from 6 participants (3 FTC/TDF, 3 placebo) had other single nucleoside reverse-transcriptase inhibitor (NRTI; M41L), nonnucleoside reverse-transcriptase inhibitor (NNRTI; K103N/E), or protease inhibitor (PI)-selected (I85V) SDRM (Table 1).
Table: M41L
High level of HIV-1 resistance in patients failing long-term first-line antiretroviral therapy in Mali.
PMID: 24855120
2014
The Journal of antimicrobial chemotherapy
Abstract: The treatment duration, median number of NRTI and NNRTI mutations and some reverse transcriptase mutations (T215Y/F/N, L210W, L74I, M41L and H221Y) were associated with the VL at virological failure.
Horizontal gene transfer from human host to HIV-1 reverse transcriptase confers drug resistance and partly compensates for replication deficits.
Abstract: The insertion developed within the context of pre-existing NRTI and NNRTI mutations (M41L, L210W, T215Y and N348I).
HIV reverse-transcriptase drug resistance mutations during early infection reveal greater transmission diversity than in envelope sequences.
PMID: 24924164
2014
The Journal of infectious diseases
Abstract: The samples were screened with sensitive polymerase chain reaction assays for the commonly transmitted M41L and K70R mutations and for K65R, which was undetected by bulk sequencing.
Analysis of the Zidovudine Resistance Mutations T215Y, M41L, and L210W in HIV-1 Reverse Transcriptase.
Abstract: CONCLUSION: We determined that a known compensatory mutation, K43E, frequently co-occurs with the drug resistance mutation M41L and may offer a significant advantage in the long-term survival of such drug resistant strains.
Abstract: SGA sequences were analyzed by Markov Chain Monte Carlo (MCMC) phylogenetic trees with molecular clock to identify and track compensatory mutation K43E correlated with primary DR mutation M41L.
Novel high-throughput screen identifies an HIV-1 reverse transcriptase inhibitor with a unique mechanism of action.
Abstract: HIV-1 resistance to zidovudine [AZT (azidothymidine)] is associated with selection of the mutations M41L, D67N, K70R, L210W, T215F/Y and K219Q/E in RT (reverse transcriptase).
Result: Consistent with previously published data, we found that RTs containing M41L/L210W/T215Y or D67N/K70R/T215F/K219Q increased the enzyme's apparent affinity for ATP (KM) and the rate of excision (kexcision) (Table 1).
Result: H
Emergence of drug resistance in human immunodeficiency virus type 1 infected patients from pune, India, at the end of 12 months of first line antiretroviral therapy initiation.
Discussion: Mutations known to be selected by TAMs (ie, M41L, D67N, K70R, L210W, T215Y/F, and K219Q/E) also confer reduced susceptibility to all currently approved nRTIs.
Discussion: The presence of 3 of the following mutations:M41L, D67N, L210W, T215Y/F, K219Q/E:is associated with resistance to didanosine.
Discussion: The presence of K65R is associated with a reduced virologic response to tenofovir.13 A reduced response also occurs in the presence of 3 or more TAMs inclusive of either
HIV mutation literature information.
PMID: 
2014
Antiviral research
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