literature

HIV mutation literature information.

HIV-1 drug-resistance surveillance among treatment-experienced and -naive patients after the implementation of antiretroviral therapy in Ghana.

PMID: 23977189 2013 PloS one

Result: This case possessed HIV-1 RT mutations M41L, V90I, A98G, M184V and T215Y, and the major NFV-resistance mutation L90M in PR.

Table: M41L

Simultaneous detection of major drug resistance mutations in the protease and reverse transcriptase genes for HIV-1 subtype C by use of a multiplex allele-specific assay.

PMID: 23985909 2013 Journal of clinical microbiology

Abstract: All the wild-type and mutant alleles were unequivocally distinguished with plasmid templates, and the limits of detection were 1.56% for K219Q and K219E, 3.13% for L76V, 6.25% for K65R, K70R, L74V, L100I, K103N, K103R, Q151M, Y181C, and I47V, and 12.5% for M41L, K101P, K101E, V106A, V106M, Y115F, M184V,

PMID: 24009694 2013 PloS one

Table: M41L

Trends in prevalence of HIV-1 drug resistance in Thailand 2009-2010.

PMID: 24038219 2013 Journal of clinical laboratory analysis

Abstract: However, only one mutation in RT gene, M41L was significantly increased.

Abstract: In 2010, M41L was increased significantly from 7.5% to 14.9%.

HIV-1 drug resistance in recently HIV-infected pregnant mother's naive to antiretroviral therapy in Dodoma urban, Tanzania.

PMID: 24053581 2013 BMC infectious diseases

Result: K103N and M41L mutations were on five lists and the K103S mutation was on four lists.

Result: K103S and M41L were found in two and one women, respectively, while M184V was not detected.

Increasing trends in primary NNRTI resistance among newly HIV-1-diagnosed individuals in Buenos Aires, Argentina.

PMID: 24093951 2013 Journal of the International AIDS Society

Method: Sequences were analyzed to identify mutations associated with reduced susceptibility to protease and RT inhibitors, as reported by the International AIDS Society-USA in 2010: RT-M41L, A62V, K65R, D67N, 69 insert, K70R, L74V,V75I, F77L, L100I, K101P, K103N, V106A, V106M, V108I, Y115F, F116Y,

Effectiveness of first-line antiretroviral therapy and correlates of longitudinal changes in CD4 and viral load among HIV-infected children in Ghana.

PMID: 24119088 2013 BMC infectious diseases

Table: M41L

Incidence and risk factors for first line anti retroviral treatment failure among Ugandan children attending an urban HIV clinic.

PMID: 24215971 2013 AIDS research and therapy

Result: Other common NRTI RAMs were the K70R (n = 22; 20%), T215Y (n = 36; 24%), M41L (n = 23; 21%), D67N (n = 15; 14%), K219Q/E (n = 14; 13%) and the L210W making 9% of the TAMs.

Highly-sensitive allele-specific PCR testing identifies a greater prevalence of transmitted HIV drug resistance in Japan.

PMID: 24358257 2013 PloS one

Method: Briefly, mutation-specific primer

Result: In one case, six mutations, M41L, K70R, M184V, M46I, M46L and L90M were detected as minority mutations by the highly sensitive assays (ID 29).

Result: The sensitive screening detected an additional one case of M41L (0.67%), two cases of K65R (1.34%), two cases of K70R (1.34%), one case of M184V (0.67%), 15 cases of M46I (19.46%), 5 cases of M46L (3.36%) and 4 cases of L90M (2.68%) as minority-level drug resistance mutations (Table 2).

Genetic diversity and drug resistance profiles in HIV type 1- and HIV type 2-infected patients from Cape Verde Islands.

PMID: 21902592 2012 AIDS research and human retroviruses

Abstract: M41L and K103N transmitted drug resistance mutations were found in 2 of 17 (12%) untreated patients.

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