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 HIV mutation literature information.


  Prevalence of drug-resistant HIV type 1 at the time of initiation of antiretroviral therapy in Portland, Oregon.
 PMID: 22697610       2013       AIDS research and human retroviruses
Abstract: Predominant RT mutations included M41L, T215C or S, and K103N.


  Low prevalence of antiretroviral resistance among HIV type 1-positive prisoners in the Southeast United States.
 PMID: 22966822       2013       AIDS research and human retroviruses
Abstract: The three most prevalent mutations were K103N 15.8% (12.0, 20.2), M184V 14.3% (10.7,18.5), and M41L 4.9% (2.8,7.8).


  Connection subdomain mutations in HIV-1 subtype-C treatment-experienced patients enhance NRTI and NNRTI drug resistance.
 PMID: 23068886       2013       Virology
Result: Standard TAMs (M41L, D67N, L210W, F214L, T215F/Y, K219N/E), were observed in POL, with P1 lacking NRTI TAMs.


  Tenofovir-based regimens associated with less drug resistance in HIV-1-infected Nigerians failing first-line antiretroviral therapy.
 PMID: 23079810       2013       AIDS (London, England)
Method: Thymidine analog mutations (TAMs) included M41L, D67N, K70R, L210W, T215F/Y, K219E/Q) that were further designated as TAM 1 (M41-L210-T215Y) or TAM 2 (D67-K70-T215F-K219).


  Antiviral resistance and correlates of virologic failure in the first cohort of HIV-infected children gaining access to structured antiretroviral therapy in Lima, Peru: a cross-sectional analysis.
 PMID: 23280237       2013       BMC infectious diseases
Result: The M184V reverse transcriptase mutation was detected in 80% of the sequenced RNA samples and tested positive in 74% and 47% by RNA-OLA and DNA-OLA, whereas thymidine associated mutations (TAMs: M41L, D67N, K70R, L210W, T215F/Y, K219Q/E) were detected in 50% of sequenced viral RNA.


  Molecular epidemiology of HIV in a cohort of men having sex with men from Istanbul.
 PMID: 23296905       2013       Medical microbiology and immunology
Abstract: In these patients, the nucleoside reverse transcriptase inhibitor (NRTI)-associated resistance mutations M41L, T215C, V75I, T69N, the non-NRTI associated mutations V106I, E138A, K103N and the protease inhibitor associated mutations Q58E and V82I were detected.


  HIV type-1 group O infection in Gabon: low prevalence rate but circulation of genetically diverse and drug-resistant HIV type-1 group O strains.
 PMID: 23409798       2013       AIDS research and human retroviruses
Abstract: M41L, M184V, and T215Y mutations were also found for one strain, making it resistant to all NRTIs by the Stanford algorithm.


  Antiretroviral drug resistance in HIV-1 therapy-naive patients in Cuba.
 PMID: 23416260       2013       Infection, genetics and evolution
Abstract: The most frequent resistance mutations were T215Y/rev (44.8%), M41L (31.0%), M184V (17.2%) and K103N (13.8%).


  Significantly improved HIV inhibitor efficacy prediction employing proteochemometric models generated from antivirogram data.
 PMID: 23436985       2013       PLoS computational biology
Method: In particular for mutations M41L, M184V, and T215Y there are differences in Phenosense predictions compared with AVG.
Result: Specific NRTI mutations that were accurately reproduced include K65R, Q151M, and T215Y, while mutations M41L and M184V are slightly underestimated, compared to previous studies.


  Human APOBEC3G-mediated hypermutation is associated with antiretroviral therapy failure in HIV-1 subtype C-infected individuals.
 PMID: 23443042       2013       Journal of the International AIDS Society
Result: M184V and T215Y/F were observed in plasma only in six and three patients, respectively, while M41L and K65R were observed in one patient each in provirus only.
Table: M41L



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