literature

HIV mutation literature information.

Monitoring HIV viral load in resource limited settings: still a matter of debate?

PMID: 23236346 2012 PloS one

Result: Among patients carrying RAMs, 12/15 (80.0%) harboured RAMs associated to thymidine analogues (TAMs) (M41L, D67N, K70R, V75I, L210W, T215F/Y) (Table 3).

Result: One patient carried Q151M mutation, associated with M41L, D67N, T215F and M184V, conferring pan-nucleoside resistance, except to tenofovir.

Result: The most frequent TAMs were T215F/Y (11/12, 91.7%), M41L (10/12, 83.3%), L210W (3/12, 27,3%), Table: M41L

HIV-1 integrase resistance among antiretroviral treatment naive and experienced patients from Northwestern Poland.

PMID: 23259737 2012 BMC infectious diseases

Result: It must be noted, that three of the patients with developed drug resistance were heavily experienced with reverse transcriptase (RT) and protease (PR) mutations (patient 1: RT: M41L, K103N, M184V, T215S; PR: L10I; patient 2: PR: M41L, V118I, K103N, M184V, L210W, T215S, RT: L10I,

Low prevalence of transmitted K65R and other tenofovir resistance mutations across different HIV-1 subtypes: implications for pre-exposure prophylaxis.

PMID: 23305651 2012 Journal of the International AIDS Society

Abstract: Tenofovir-associated resistance mutations included K65R, K70E, T69-insertion and >=3 thymidine analogue mutations (TAMs), inclusive of M41L or L210W.

Method: Tenofovir-associated resistance mutations included K65R, T69 insertion, K70E and >=3 thymidine-analogue mutations (TAMs;

Result: In addition to K65R, other transmitted tenofovir-associated resistance mutations included K70E, seen in three subtype B sequences (0.015%, 95% CI: 0.004 to 0.04) and three or more TAMs (inclusive of either M41L or L210W) seen in 54/19,823 sequences (0.27%, 95% CI: 0.2 to 0.4), the majority of which (46/54) were subtype B sequences.

Impact of HIV type 1 subtype on drug resistance mutations in Nigerian patients failing first-line therapy.

PMID: 20964479 2011 AIDS research and human retroviruses

Abstract: Multivariate analysis showed that CRF02_AG was less likely to have the M41L mutation compared to other subtypes [adjusted odds ratio (AOR) = 0.35; p = 0.022].

Emerging transmitted drug resistance in treatment-naive human immunodeficiency virus-1 CRF06_cpx-infected patients in Estonia.

PMID: 20964489 2011 Scandinavian journal of infectious diseases

Abstract: A total of 2.8% of sequences harboured mutations indicating nucleoside/nucleotide reverse transcriptase inhibitor resistance (M41L, M184V, M184I, T215C and T215D), 2.1% non-nucleoside reverse transcriptase inhibitor resistance (K103N, P225H) and 2.8% protease inhibitor resistance (M46I, L90M).

Minority HIV mutation detection in dried blood spots indicates high specimen integrity and reveals hidden archived drug resistance.

PMID: 21130027 2011 Journal of clinical virology

Abstract: STUDY DESIGN: Evaluate nucleic acids from the DBS of 33 antiretroviral-experienced subtype B-infected subjects for minority M41L, K65R, K70R, K103N, Y181C, M184V, and T215Y/F mutations by real-time PCR.

"K70Q adds high-level tenofovir resistance to ""Q151M complex"" HIV reverse transcriptase through the enhanced discrimination mechanism."

PMID: 21249155 2011 PloS one

Introduction: Increased excision of NRTIs is imparted by Excision Enhancement Mutations, typically M41L, D67N, K70R, T215Y/F, L210W, and K219E/Q (also known as Thymidine Associated Mutations, or TAMs).

Differences in reversion of resistance mutations to wild-type under structured treatment interruption and related increase in replication capacity.

PMID: 21297946 2011 PloS one

Introduction: The authors reported a faster rate of reversion for primary resistance mutations (K70R, M184I/V, T215Y/F in RT, and D30N, M46I/L, V82A, L90M in PR) compared to secondary mutations (M41L, D67N, T69D/N, L210W, K219Q/E in RT and L10I/V, L63P, A71V/T, V77I in PR)

Prevalence of HIV type 1 antiretroviral drug resistance mutations in Vietnam: a multicenter study.

PMID: 21366425 2011 AIDS research and human retroviruses

Abstract: The most common DRMs observed were M184V, V75A/M, M41L, and K65R (NRTI) and K103N, G190A, and Y181C (NNRTI).

Clinical significance of HIV reverse-transcriptase inhibitor-resistance mutations.

PMID: 21449841 2011 Future microbiology

Abstract: Several large-scale HIV-1 genotypic analyses have revealed that the most prevalent nucleos(t)ide analog RT inhibitor (NRTI)-resistance mutation is M184V/I followed by a series of thymidine analog-associated mutations: M41L, D67N, K70R, L210W, T215Y/F and K219Q/E.

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