literature

HIV mutation literature information.

Drug Resistance Mutations Against Protease, Reverse Transcriptase and Integrase Inhibitors in People Living With HIV-1 Receiving Boosted Protease Inhibitors in South Africa.

PMID: 32265875 2020 Frontiers in microbiology

Result: The M41L mutation occurred in three (3%) patients receiving AZT plus 3TC, and in one (1%) patient receiving 3TC plus ATV/r.

Table: M41L

HIV-1 Sub-Subtype A6: Settings for Normalised Identification and Molecular Epidemiology in the Southern Federal District, Russia.

PMID: 32331438 2020 Viruses

Result: RAMs I54AVPR, L90MPR, M41LRT, D67NPR, and T215FPR were significantly more frequent in subtype G isolates.

The characteristics of pretreatment HIV-1 drug resistance in western Yunnan, China.

PMID: 32381145 2020 Epidemiology and infection

Result: Among the key DRMs for NRTIs, K65R (1.6%, 5/322) conferred high-level resistance, T69D (0.3%, 1/322) conferred intermediate resistance and M41L (0.6%, 2/322), D67N (0.6%, 2/322) and T215D (0.3%, 1/322) conferred low-level resistance.

Table: M41L

Prevalence of human immunodeficiency virus-1 drug-resistant mutations among adults on first- and second-line antiretroviral therapy in a resource-limited health facility in Busia County, Kenya.

PMID: 33654530 2020 The Pan African medical journal

Table: M41L

Virologic suppression in patients with a documented M184V/I mutation based on the number of active agents in the antiretroviral regimen.

PMID: 33014372 2020 SAGE open medicine

Table: M41L

Patterns of acquired HIV-1 drug resistance mutations and predictors of virological failure in Moshi, Northern Tanzania.

PMID: 32986709 2020 PloS one

Result: Identified TAMs were T215YF (n = 9), K219QE (n = 7), K70R (n = 7), D67N (n = 6), M41L (n = 4), and L210W (n = 3) (Table 3).

Table: M41L

Discussion: Two of these samples had M41L and T215Y TAMs, a combination which further enhances cross-resistance to all US FDA approved NRTIs, a phenomenon known as Multi-NRTI resistance.

Review of Doravirine Resistance Patterns Identified in Participants During Clinical Development.

PMID: 32925358 2020 Journal of acquired immune deficiency syndromes (1999)

Table: M41L

First case of Dolutegravir and Darunavir/r multi drug-resistant HIV-1 in Cameroon following exposure to Raltegravir: lessons and implications in the era of transition to Dolutegravir-based regimens.

PMID: 32843050 2020 Antimicrobial resistance and infection control

Conclusion: Detected RAMs were M41L, K70Q, V75I, Q151M, M184V and T215F for NRTI; K103N and V108I for NNRTI; and L10F, K20I, M36I, M46I, I47V, I54L, L63H, L76V, V82S and L89I for PI/r.

[Prevalence of transmitted drug resistance in HIV-infected treatment-naive patients in Chile].

PMID: 33844760 2020 Revista medica de Chile

Abstract: The mutations in reverse transcriptase were M41L, L210W, D67N, K70E, M184V, K103N (6.36%, 95% CI 3.5-10.4), G190A, E138A, K101E, and I84V in protease.

HIV-1 Drug Resistance in ART-Naive Individuals in Myanmar.

PMID: 32368103 2020 Infection and drug resistance

Discussion: Some SDRMs, including NRTI-related mutations (M41L, D67E/G/N, K70E/R, M184V, T215any, and K219any) and NNRTI-related mutations (K101E/P, K103N/S, V106A/M, Y181any, G190any, and P225H) were reported in Myanmar.

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