literature

HIV mutation literature information.

Switching to Elvitegravir/Cobicistat/Emtricitabine/Tenofovir Alafenamide in Adults With HIV and M184V/I Mutation.

PMID: 33315694 2021 Journal of acquired immune deficiency syndromes (1999)

Table: M41L

Distribution characteristics of drug resistance mutations of HIV CRF01_AE, CRF07_BC and CRF08_BC from patients under ART in Ganzhou, China.

PMID: 34402512 2021 The Journal of antimicrobial chemotherapy

Abstract: The most common DRMs of these three subtypes were K103N and M184V, while the mutation frequencies of M41L, D67N, K70R, K101E, V106M, Y181C, K219E, H221Y and N348I were obviously different among subtypes.

Transmitted HIV-1 drug resistance in a large international cohort using next-generation sequencing: results from the Strategic Timing of Antiretroviral Treatment (START) study.

PMID: 33369017 2021 HIV medicine

Abstract: Using the 2% detection threshold, individual DRMs with the highest prevalence were: PI M46IL (5.5%), RT K103NS (3.5%), RT G190ASE (3.1%), T215ISCDVEN (2.5%), RT M41L (2.2%),

Result: The T215 revertants and, to a lesser extent, M41L were mostly high-level variants representing the majority of the quasispecies.

Result: The most common NRTI DRMs were T215 revertants (2.5%), M41L (2.2%), and K219QENR (1.7%).

HIV drug resistance and HIV transmission risk factors among newly diagnosed individuals in Southwest China.

PMID: 33557775 2021 BMC infectious diseases

Result: Patients infected with the CRF01_AE subtype were the most likely to develop NRTI-associated mutations; the most common mutations were M41L (0.17%) and D67G (0.17%).

HIV-1 subtypes and drug resistance in children during antiretroviral therapy in Brazil.

PMID: 33788308 2021 Journal of medical virology

Abstract: The most common primary mutations found were M184V (29.5%), K103N (25%), M41L (9.8%), T215Y (8.3%), and G190A (8.3%).

Virologic outcomes of switching to dolutegravir functional mono- or dual therapy with a non-cytosine nucleoside analog: a retrospective study of treatment-experienced, patients living with HIV.

PMID: 33941212 2021 AIDS research and therapy

Result: The other patient was switched from TDF/FTC/EVG/c to DTG/ABC/3TC (Table 2, Patient 6) and historical genotypic testing revealed an M184V/I, M41L, T215Y and L74/I which predicted that DTG was the only fully active agent in the study DCR.

Table: M41L

Discussion: Among the three patients on functional dual therapy with persistent viremia and documented non-adherence, two were on DTG/ABC and only had baseline M184V/I whereas the other was on DTG/TDF and had baseline M184V/I, M41L and T215Y.

Temporal Trends in HIV-1 Mutations Used for the Surveillance of Transmitted Drug Resistance.

PMID: 34064774 2021 Viruses

Method: Thymidine-analog mutations were defined as the NRTI-SDRMs M41L, D67N/G/E, K70R, L210W, T215Y/F/S/C/D/E/I/V, and K219Q/E/N/R.

Result: Three mutations demonstrated a change in prevalence among RTI-naive persons: M41L, F77L, and T215D each decreased in prevalence.

Transmitted drug resistance and transmission clusters among HIV-1 treatment-naive patients in Guangdong, China: a cross-sectional study.

PMID: 34488793 2021 Virology journal

Discussion: The most frequent NRTI-associated mutations in our study were M184V and L210W, while they are M41L and D67G in Southwest China and T215C/D in Iceland and the south-central United States.

Nucleoside Reverse-Transcriptase Inhibitor Resistance Mutations Predict Virological Failure in Human Immunodeficiency Virus-Positive Patients During Lamivudine Plus Dolutegravir Maintenance Therapy in Clinical Practice.

PMID: 34327247 2021 Open forum infectious diseases

Method: The variables expressing NRTI RAMs were identified as follows: (1) presence versus absence of any NRTI RAM; (2) presence versus absence of at least 1 TAM (M41L, D67N, K70R, L210W, T215Y/F, K219Q/E); (3) presence versus absence of M184V/I (with or without other RAMs); (4) presence versus absence of M184V/I not associated with TAMs; (5) presence versus absence of M184V/I combined with at least 1 TAM.

Table: M41L

High Detection Rate of HIV Drug Resistance Mutations among Patients Who Fail Combined Antiretroviral Therapy in Manaus, Brazil.

PMID: 34212033 2021 BioMed research international

Result: Thymidine analog mutations (TAM) were detected in 35.4% of the individuals [17.1% (14/82) TAM-1 (including M41L, L210W, and T215Y) and 20.7% (17/82) TAM-2 (including D67N, K70R, T215F, and K219Q/E)].

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