literature

HIV mutation literature information.

Low prevalence of transmitted drug resistance among newly diagnosed HIV-1 patients in Latvia.

PMID: 20981787 2010 Journal of medical virology

Abstract: All four patients displayed single, but different resistance mutations (M46I, F53L, M41L, and G190A).

Proteochemometric modeling of the susceptibility of mutated variants of the HIV-1 virus to reverse transcriptase inhibitors.

PMID: 21179544 2010 PloS one

Result: E.g., a pathway that the virus uses often to escape from thymidine analogs is by the mutation T215Y (or T215F), followed by M41L, which in turn is followed by L210W.

Result: Figure 3 presents screenshots of outputs from the web page, illustrating the predicted susceptibilities for two patterns of mutations: K65R+M184V (Panel A) and M41L+L210W+T215Y (Panel B).

Result: On the other hand, the RT variant that harbors the triple mutation M41L+L210W+T215Y is highly resistant to AZT, while it shows an unchanged susceptibility to d

HIV-1 drug-resistance patterns among patients on failing treatment in a large number of European countries.

PMID: 21390473 2010 Acta dermatovenerologica Alpina, Pannonica, et Adriatica

Abstract: Ninety percent of sequences with genotypic resistance harbored M184V, M41L, K103N, D67N, and/or T215Y.

Persistent minority K103N mutations among women exposed to single-dose nevirapine and virologic response to nonnucleoside reverse-transcriptase inhibitor-based therapy.

PMID: 19133804 2009 Clinical infectious diseases

Table: M41L

Emergence of multiclass drug-resistance in HIV-2 in antiretroviral-treated individuals in Senegal: implications for HIV-2 treatment in resouce-limited West Africa.

PMID: 19143530 2009 Clinical infectious diseases

Abstract: HIV-1-associated thymidine analogue mutations (M41L, D67N, K70R, L210W, and T215Y/F) were not observed, with the exception of K70R, which was present together with K65R and Q151M in a strain from 1 patient.

Result: HIV-1-associated thymidine analogue mutations (M41L, D67N, K70R, L210W, T215Y/F, and K219Q/E) were not found, with the exception of K70R, which was present in a strain from 1 patient (in conjunction with K65R

Genetic analysis of HIV type 1 strains from newly infected untreated patients in cyprus: high genetic diversity and low prevalence of drug resistance.

PMID: 19182918 2009 AIDS research and human retroviruses

Abstract: One patient (2.7%) had an M41L/M and another patient (2.7%) an M184V amino acid substitution in the reverse transcriptase (RT) associated with high-level resistance to RT inhibitors.

Apricitabine does not select additional drug resistance mutations in tissue culture in human immunodeficiency virus type 1 variants containing K65R, M184V, or M184V plus thymidine analogue mutations.

PMID: 19223637 2009 Antimicrobial agents and chemotherapy

Abstract: Human immunodeficiency virus type 1 containing the reverse transcriptase mutation M184V or K65R or mutations M41L, M184V, and T215Y did not accumulate additional resistance mutations in the reverse transcriptase when increasing amounts of apricitabine drug pressure were applied.

Antiretroviral drug susceptibility among drug-naive adults with recent HIV infection in Rakai, Uganda.

PMID: 19276794 2009 AIDS (London, England)

Abstract: Mutations used for genotypic surveillance of transmitted antiretroviral drug resistance were identified in six samples: three had nucleoside reverse transcriptase inhibitor (NRTI) surveillance mutations (two had M41L, one had K219R), and three had protease inhibitor surveillance mutations (I47V, F53L, N88D); none had nonnucleoside reverse transcriptase inhibitor (NNRTI) surveillance mutations.

Result: Seven of the 104 samples (6.7%) had a mutation associated with NRTI resistance (one mutation in each sample: M41L (n = 2), E44D<

Emergence of primary NNRTI resistance mutations without antiretroviral selective pressure in a HAART-treated child.

PMID: 19277127 2009 PloS one

Table: M41L

Antiretroviral drug resistance in HIV-2: three amino acid changes are sufficient for classwide nucleoside analogue resistance.

PMID: 19358668 2009 The Journal of infectious diseases

Result: In contrast to HIV-1NL4-3, HIV-2ROD mutants that harbored M41L, T215Y, or both substitutions showed no detectable resistance to AZT in the single-cycle assay (<2-fold increase in EC50 relative to WT HIV-2ROD) (figure A3 in appendix A, which appears only in the electronic version of the Journal).

Result: We constructed HIV-1NL4 3 and HIV-2ROD variants encoding 2 pivotal replacements in the TAM series (M41L and T215Y) and compared their sensitivities to AZT.

Discussion: Second, 2 key replacements in the TAM pathway (M41L and T215Y) have no effect on AZT susceptibility in HIV-2 in culture (figure A3 in appendix A, which appears only in the electronic version of the Journal).

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