literature

HIV mutation literature information.

Drug-resistance surveillance among newly HIV-1 diagnosed individuals in Buenos Aires, Argentina.

PMID: 17545713 2007 AIDS (London, England)

Abstract: RESULTS: We found that 12 (4.2%) of the 284 samples sequenced harbored primary resistance mutations, of which K103N, M41L and V108I were most prevalent.

Molecular mechanisms of bidirectional antagonism between K65R and thymidine analog mutations in HIV-1 reverse transcriptase.

PMID: 17589186 2007 AIDS (London, England)

Abstract: In addition, the TAMs combination D67N/K70R/T215F/K219Q decreased susceptibility to the L-nucleotide lamivudine by a discrimination mechanism, whereas the M41L/L210W/T215Y combination had little effect on susceptibility to lamivudine.

Abstract: RESULTS: The addition of K65R to two clinically relevant combinations of TAMs (M41L/L210W/T215Y or D67N/K70R/T215F/K219Q) significantly reduced the recombinant enzymes' ability to excise all chain-terminating

PMID: 17668565 2007 Antiviral therapy

Abstract: The first case had an N42D mutation in the HR1 region of the gp41, along with transmitted resistance mutations in the protease (D30N, M361, N88D) and in the RT (M41L, L210W, T215D).

Changing rates and patterns of drug resistance mutations in antiretroviral-experienced HIV-infected patients.

PMID: 17678470 2007 AIDS research and human retroviruses

Abstract: Mutations T215Y/F, M184V, and M41L were the most frequent for NRTI.

Impact of HIV-1 reverse transcriptase polymorphism F214L on virological response to thymidine analogue-based regimens in antiretroviral therapy (ART)-naive and ART-experienced patients.

PMID: 17955437 2007 The Journal of infectious diseases

Abstract: In ART-experienced patients, results were similar, and larger differences in virological response associated with the detection of 214L versus F were observed in patients with M41L/T215Y and mixed TAM profiles detected before the initiation of cART.

Impact of the number of failed therapeutic regimes on the development of resistance mutations to HIV-1 in northeast Brazil.

PMID: 17962868 2007 The Brazilian journal of infectious diseases

Abstract: There was a significant increase in resistance mutations V82A/F/L/T, I84V, L90M, M41L, K70R, L210W, T215Y/F and K219Q/E in MF.

Improved interpretation of genotypic changes in the HIV-1 reverse transcriptase coding region that determine the virological response to didanosine.

PMID: 18008248 2007 The Journal of infectious diseases

Abstract: The best correlation with response was found with the derived score (M41L x 2) + E44D/A/G + T69D/S/N/A + (L210W x 2) + T215Y or revertants + L228H/R - D123E/N/G/S, by use of which viruses were categorized as being susceptible (score < or =0), as having intermediate resistance (1-3), and as being resistant (> or =4) to didanosine.

Potent activity of the HIV-1 maturation inhibitor bevirimat in SCID-hu Thy/Liv mice.

PMID: 18043758 2007 PloS one

Method: The AZT-resistant (M41L, T215Y) R5X4 clinical HIV-1 isolate JD was kindly provided by Mike McCune and prepared by cocultivation of patient peripheral blood mononuclear cells (PBMCs) and expansion in phytohemagglutinin (PHA)-activated PBMCs.

N348I in the connection domain of HIV-1 reverse transcriptase confers zidovudine and nevirapine resistance.

PMID: 18052601 2007 PLoS medicine

Method: The M41L, L210W, T215Y, and N348I mutations were introduced into WT HIV-1LAI RT by site-directed mutagenesis using the QuikChange Mutagenesis kit.

Method: The analysis was performed for N348I and for each of the TAMs: M41L, D67N, K70R, L210W, T215Y/F, and K219Q/E.

Result: Accordingly, we compared the AZT susceptibility of HIV-1 containing M184V and TAMs (M41L and T215Y) (NL/2AZT + 184) and HIV-1 containing M184V

[Resistance to anti-retroviral therapy in Chilean patients with HIV-1 from 2002 to 2005].

PMID: 18180829 2007 Revista medica de Chile

Abstract: The most common mutations found were T215Y (46%), L10F (44%), Ml84V (3896), K103N (35%) and M41L (32%).

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