literature

HIV mutation literature information.

Does GSS still maintain relevance on HAART outcome after the introduction of newest active antiretroviral drugs? 48 weeks results.

PMID: 22211659 2011 Current HIV research

Abstract: About 60% of tests reported L10FIRVC, M36ILV, M46IL, I54VLAMTS, V82AFTSLI, and L90M mutations in the protease region.

Protease polymorphisms in HIV-1 subtype CRF01_AE represent selection by antiretroviral therapy and host immune pressure.

PMID: 20009919 2010 AIDS (London, England)

Discussion: M36I is a common nonsubtype B polymorphism in the absence of drug pressure and also has a higher replication capacity than subtype B wild type virus.

Discussion: In this study, polymorphisms in the CRF01_AE protease gene were common, with the M36I polymorphism being the most frequent.

Discussion: Interestingly, R41K and H69K have not previously been reported to be associated with any currently available protease inhibitors, and the predicted HLA binding affinities at the epitope located at amino acid positions 34-42 decreases 19-40 fold when E35D, M36I and R41K are present.

HIV drug resistance surveillance using pooled pyrosequencing.

PMID: 20174661 2010 PloS one

Table: M36I

Prevalence and clinical significance of HIV drug resistance mutations by ultra-deep sequencing in antiretroviral-naive subjects in the CASTLE study.

PMID: 20532178 2010 PloS one

Table: M36I

Comparison of protease inhibitor (PI) resistance-associated mutations between PI-naive and PI-experienced HIV-1 infected patients in Thailand where subtype A/E is predominant.

PMID: 20636277 2010 Current HIV research

Abstract: The most common secondary PI-RAMs in both groups were M36I (91%), H69K (34%) and L89M (30%).

Partially active HIV-1 Vif alleles facilitate viral escape from specific antiretrovirals.

PMID: 20729708 2010 AIDS (London, England)

Abstract: More specifically, K22H viruses harbored significantly more G16E and M36I in protease than in those isolated from pretreated patients harboring WT K22 viruses.

Prevalence of drug resistance and associated mutations in a population of Hiv-1+ Puerto Ricans in 2005.

PMID: 23875516 2010 Boletin de la Asociacion Medica de Puerto Rico

Result: As shown in Table III, the PI resistance-associated specific mutations with the highest degree of expression for 2005 were L63P (73.6%), M36I (26.2%), and L90M (21.0%).

Distinct resistance mutation and polymorphism acquisition in HIV-1 protease of subtypes B and F1 from children and adult patients under virological failure.

PMID: 18992847 2009 Infection, genetics and evolution

Abstract: In untreated patients, mutations L10V, K20R, and M36I were more frequent in subtype F1, while L63P, A71T, and V77I were more prevalent in subtype B.

Method: In the quantitative analysis, L63P and M36I were not counted as minor mutations for subtypes B and F1, respectively, as they represent frequent polymorphisms found in those respective subtypes.

Method: Mutations L10F/I/R/V, K20M/R, L24I, L33F, M36I, F53L, I54V/L/A/M/T/S<

Antiretroviral drug susceptibility among drug-naive adults with recent HIV infection in Rakai, Uganda.

PMID: 19276794 2009 AIDS (London, England)

Table: M36I

Absence of genotypic drug resistance and presence of several naturally occurring polymorphisms of human immunodeficiency virus-1 CRF06_cpx in treatment-naive patients in Estonia.

PMID: 19382254 2009 Journal of medical virology

Abstract: The most common polymorphisms in the PR region were K14R, M36I, H69K, and L89M seen in 96%, 100%, 99%, and 100%, respectively.

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