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 HIV mutation literature information.


  Detection of drug resistance mutations as a predictor of subsequent virological failure in patients with HIV-1 viral rebounds of less than 1,000 RNA copies/ml.
 PMID: 17607772       2007       Journal of medical virology
Abstract: The M184V/I mutation was the most prevalent but in several patients a combination of multiple mutations was detected.


  Systematic evaluation of allele-specific real-time PCR for the detection of minor HIV-1 variants with pol and env resistance mutations.
 PMID: 17662474       2007       Journal of virological methods
Abstract: The assays achieved sensitivities of <1% for the D30N mutation in HIV-1 PR, M184V and I mutations in RT, and V38A in gp41.


  Validation of the SCID-hu Thy/Liv mouse model with four classes of licensed antiretrovirals.
 PMID: 17668043       2007       PloS one
Abstract: Moreover, HIV-1 replication in these mice was genetically stable; treatment of the mice with lamivudine did not result in the M184V substitution in reverse transcriptase, and the multidrug-resistant NY index case HIV-1 retained its drug-resistance substitutions.
Result: Importantly, HIV-1 NL4-3 replication in these mice was genetically stable over the 21-day infection period; there was no evidence of the RT M184V substitution in viral RNA amplified by RT-PCR and sequenced from 32 of 32 Thy/Liv implants collected from mice treated with 3TC in these seven experiments (data not shown).
Result: We reported the activity of the 3TC analog dOTC against 3TC-resistant HIV-1 NL4-3/M184V in the SCID-hu Thy/Liv model.


  Changing rates and patterns of drug resistance mutations in antiretroviral-experienced HIV-infected patients.
 PMID: 17678470       2007       AIDS research and human retroviruses
Abstract: Mutations T215Y/F, M184V, and M41L were the most frequent for NRTI.


  Polymorphism and drug selected mutations of reverse transcriptase gene in 102 HIV-1 infected patients living in China.
 PMID: 17705165       2007       Journal of medical virology
Abstract: (2) T215Y (23%), M184V (20%), and TAMs (15.4%) in patients receiving d4T + 3TC + EFV.
Abstract: In treated patients, two patterns of resistance associated mutations (RAMs) were observed: (1) K65R (9.8%), L74V (7.4%), M184V (7.4%), Q151M (5%), and thymidine analogue mutations (TAMs) (9.3%) including T215Y (5.5%), in patients who underwent ddI + d4T + NVP.


  Utility of repeat genotypic resistance testing and clinical response in patients with three class resistance and virologic treatment failure.
 PMID: 17711379       2007       AIDS patient care and STDs
Abstract: On 3C-GRT 2, all patients retained essentially identical mutations, with the exception of the loss of the M184V mutation in 6 patients.


  Quadruple nucleoside therapy with zidovudine, lamivudine, abacavir and tenofovir in the treatment of HIV.
 PMID: 17713153       2007       Antiviral therapy
Abstract: The presence of L210W, or at least two of the mutations 41L, 67N, 70R, 215F/Y or 219Q/E, at or before baseline seems to be a predictor of non-response, whereas the presence of M184V does not impede virological response and might even be advantageous.


  Variations in reverse transcriptase and RNase H domain mutations in human immunodeficiency virus type 1 clinical isolates are associated with divergent phenotypic resistance to zidovudine.
 PMID: 17724152       2007       Antimicrobial agents and chemotherapy
Abstract: Although some mutations were also observed in the connection domain, the simultaneous presence of the L74V and M184V mutations was the most significant determinant of phenotypic resistance to ZDV in patients infected with viruses with TAMs.


  Genetic polymorphisms and resistance mutations of HIV type 2 in antiretroviral-naive patients in Burkina Faso.
 PMID: 17725411       2007       AIDS research and human retroviruses
Abstract: Two samples harbored known resistance mutations: M184V RT mutation in one and Q151M with M184V in the other.


  Genotype testing and antiretroviral resistance profiles from HIV-1 patients experiencing therapeutic failure in northeast Brazil.
 PMID: 17873990       2007       The Brazilian journal of infectious diseases
Abstract: The most frequent mutations were: L90M, M184V and K103N related to PI's, NRTI's and NNRTI's, respectively.



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