Result: The result shows that molecular marker mutations, which were found in more than 50% of treatment failure patients, were M184V (100%), Discussion: Molecular marker mutations in more than 50% of treatment failure patients were M184V, T215A/Y/F, D67N/G, and M41L.
Discussion: Molecular markers of TAMs, M184V (100%), T215A/Y/F (88.2%), D67N/G (76.5%), and M41L (58.8%), were found in more than 50% of treatment failure patients.
Discussion: The pattern of resistance-associated mutations found in this study differs to that found in Maumere, East Nusa Tenggara, except for M184V.
Resistance profile of children and adolescents infected with HIV-1 in urban areas in Togo.
Abstract: The mutations associated with the most frequent NRTIs were M184V, Y181C, and T215Y.
Evaluation of Acquired HIV Drug Resistance among People Living with HIV Who Have Taken Antiretroviral Therapy for 9-15 Months in 14 Triangular Clinics in Iran, 2015-2016.
Abstract: M184I/V mutation was the most frequent (31.6%) mutation among NRTI-based regimens.
Accumulation of HIV-1 Drug Resistance Mutations After First-Line Immunological Failure to Evaluate the Options of Recycling NRTI Drugs in Second-Line Treatment: A Study from South India.
PMID: 27460519
2017
AIDS research and human retroviruses
Abstract: The result shows that predominant nucleos(t)ide reverse transcriptase inhibitor (NRTI) mutations were M184V/I (87.3% in FTF and 79% in STF) followed by TAMs (53.4% in FTF and 54.5% in STF).
Simplification to dual therapy (atazanavir/ritonavir + lamivudine) versus standard triple therapy [atazanavir/ritonavir + two nucleos(t)ides] in virologically stable patients on antiretroviral therapy: 96 week results from an open-label, non-inferiority, randomized clinical trial (SALT study).
PMID: 27629070
2017
The Journal of antimicrobial chemotherapy
Abstract: One patient taking ATV/r + 2NUCs developed resistance mutations (M184V and L63P).
HIV-1 antiretroviral drug resistance patterns in patients failing NNRTI-based treatment: results from a national survey in South Africa.
PMID: 27659733
2017
The Journal of antimicrobial chemotherapy
Abstract: After M184V/I (82.7%), K65R was the most common NRTI mutation (45.8%).
Rapid Detection of Common HIV-1 Drug Resistance Mutations by Use of High-Resolution Melting Analysis and Unlabeled Probes.
PMID: 27795333
2017
Journal of clinical microbiology
Abstract: The analytical sensitivities of the HRMA assays were 5% of mixed species for K103N and Y181C and 20% for M184V.
Abstract: When applied to 153 HIV-1 patient specimens previously genotyped by Sanger population sequencing, HRMA correctly assigned drug sensitivity or resistance profiles to 80% of the samples at codon 103 (K103K/N) (Cohen's kappa coefficient [kappa] > 0.6; P < 0.05), 90% at 181 (Y181Y/C) (kappa > 0.74, P < 0.05), and 80% at 184 (M184M/V) (kappa > 0.62; P < 0.05).
Infrequent development of drug resistance in HIV-1-infected treatment-naive subjects after 96 weeks of treatment with elvitegravir/cobicistat/emtricitabine/tenofovir alafenamide or elvitegravir/cobicistat/emtricitabine/tenofovir disoproxil fumarate.
Abstract: Primary resistance development to ARVs of the regimen occurred in 10 of 24 subjects in the E/C/F/TAF arm, and 8 of 24 subjects in the E/C/F/TDF arm (E/C/F/TAF: M184V/I, n=9; integrase strand-transfer inhibitor resistance-associated mutations [INSTI-RAMs], n=8; K65R/N, n=2; E/C/F/TDF: M184V/I, n=6; INSTI-RAMs, n=5; K65R/N, n=3).
Early virological failure and HIV drug resistance in Ugandan adults co-infected with tuberculosis.
Abstract: Genotypic resistance testing was available for 16/22 (72.7%) patients, of which 15 (93.8%) had at least one major mutation, most commonly M184V (81.2%) and K103NS (68.8%).
Result: The most common mutations found were M184V (81.2%) reflecting treatment with the nucleoside/nucleotide reverse transcriptase inhibitor (NRTI) lamivudine, and K103NS (68.8%) reflecting prior treatment with the non-nucleoside reverse transcriptase inhibitors (NNRTI) nevirapine or efavirenz.
Discussion: M184 V and K103NS were the most prevalent mutations found, reflecting prior treatment with lamivudine, efavirenz or nevirap
Polymorphisms and Mutational Covariation Associated with Death in a Prospective Cohort of HIV/AIDS Patients Receiving Long-Term ART in China.
Result: For example, M41L and D67N had 16 (D218E, E44A, G190S, G196E, H221Y, I142V, K10
Discussion: For example, T39A and K43E had three (M41L, K43E, and M184V) and seven (D67N, L74V, K101E, L210W, M184V, T215Y, and E224D) target drug resistance mutations, respectively.
HIV mutation literature information.
PMID: 
2018
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