Characterization of human immunodeficiency viruses resistant to oxathiolane-cytosine nucleosides.
PMID: 7684216
1993
Antimicrobial agents and chemotherapy
Abstract: Sequence analysis of amplified reverse transcriptase from a patient who had received (-)-BCH-189 therapy for 4 months demonstrated a mixture of the Met-184-to-Val (GTG) mutation and the parental genotype, indicating that the Met-184 mutation can occur in vivo.
Rapid in vitro selection of human immunodeficiency virus type 1 resistant to 3'-thiacytidine inhibitors due to a mutation in the YMDD region of reverse transcriptase.
Abstract: All mutants with Met184-->Val were cross-resistant to 3TC and FTC.
Abstract: Interestingly, when both Met184-->Val and Tyr181-->Cys substitutions were present, highly resistant virus reverted to complete AZT sensitivity.
Abstract: The Met184-->Val mutation did not influence nevirapine resistance, but resistance to AZT was suppressed.
Abstract: When the mutation Met184-->Val was introduced into the infectious clone HXB2, this change alone accounted for the resistance (> 1000-fold) seen with both 3TC and FTC, and for a 5- to 15-fold reduction in sensitivity to their (+) enantiomers.
Convergent combination therapy can select viable multidrug-resistant HIV-1 in vitro.
Abstract: We found no evidence for 'replication incompatible' combinations of resistance mutations, although a mutation (M184-->V) conferring oxathiolane-cytosine nucleoside resistance in reverse transcriptase completely suppressed AZT resistance in a triple-resistant background.
HIV mutation literature information.
PMID: 
1993
Antimicrobial agents and chemotherapy
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