[Genetic analysis of the mutations in HIV-1 infected population in Ecuador].
PMID: 29652972
2018
Revista chilena de infectologia
Abstract: Results The most frequent mutations were M184V/I, K101E/P/H, K103N/S, D30N, M46L/I, I54L/M, V82T/F/A/S/L and L90M in adults and F77L, K103N/S, M46L/I, V82T/F/A/S/L and L90M in children.
Risk factors and outcomes for the Q151M and T69 insertion HIV-1 resistance mutations in historic UK data.
Result: Only 3% of patients showed no other mutation, and the most common associated major reverse transcriptase mutations were M184V (47%), K103N (35%) and K65R (29%).
A week-48 randomized phase-3 trial of darunavir/cobicistat/emtricitabine/tenofovir alafenamide in treatment-naive HIV-1 patients.
Abstract: One patient (D/C/F/TAF) was identified with M184I/V conferring resistance to emtricitabine.
Result: An M184V/I mutation associated with phenotypic resistance to emtricitabine and lamivudine was identified in one patient receiving D/C/F/TAF.
Discussion: M184V was detected pretreatment by deep sequencing (Illumina MiSeq) as a minority variant (9.4%).
Discussion: Only one patient (D/C/F/TAF) was found to have M184I/V, conferring resistance to emtricitabine; this patient also had a transmitted K103N mutation at screening.
Seroconversion on preexposure prophylaxis: a case report with segmental hair analysis for timed adherence determination.
Introduction: In that case, if the patient was not fully adherent to PrEP when exposed to HIV in the past, the patient could have developed the NRTI-resistant mutations (M184V, K70T, and K65R) through the selective pressure of FTC/TDF prophylaxis after acquiring a virus carrying the K103N mutation.
Introduction: On day 2, his HIV-1 RNA was 27 316 copies/ml, and genotyping (by population sequencing) subsequently revealed significant mutations in the reverse transcriptase gene, including M184V [which reduces susceptibility to lamivudine (3TC) / emtricitabine (FTC)], K65R (which reduces susceptibility to TDF), K70T (which reduces susceptibility to TDF and FTC/3TC), and the
HIV-1 transmission networks across Cyprus (2010-2012).
Result: The second study subject, also a Romanian citizen living in Cyprus, was also infected with a sub-subtype F1strain dual-class RT and PI resistant strain carrying D67N, K70R, M184V, T215F, Y181C, M46L, I54V and V82F mutations associated with drug resistance.
Design, synthesis and biological evaluation of substituted (+)-SG-1 derivatives as novel anti-HIV agents.
Abstract: The result showed that RT- E138K/M184V mutant virus conferred 4.7-9.1-fold resistance to 4c, 4f, 2 and 6b, but only showed slight resistance to 4b (2-fold) which was better than SG-1.
Appearance of Drug Resistance Mutations Among the Dominant HIV-1 Subtype, CRF01_AE in Maumere, Indonesia.
Result: NRTI resistance-associated mutations found in this population included M184 V (n = 3, 6.67%), M41 L (n = 2, 4.44%), T215F (n = 2, 4.44%), L74F/V (n = 2, 4.44%), D67G (n = 1, 2.22%) and K70Q (n = 1, 2.22%) (Figure1).
Discussion: Furthermore, M184 V is the most frequently detected NRTI resistance mutation, which was also found in previous studies.
Discussion: The major TDRMs observed in this study have been reported in a previous study of HIV Drug Resistance among ART-failure individuals in Yunnan Province, which figured out mutations such as M184 V/I, K103 N,
Short Communication: Discordance in Drug Resistance Mutations Between Blood Plasma and Semen or Rectal Secretions Among Newly Diagnosed HIV-1-Infected Thai Men Who Have Sex with Men.
PMID: 29756454
2018
AIDS research and human retroviruses
Abstract: Three participants had DRAMs in anogenital compartments that were not detected in blood plasma-one had DRAMs in semen that was not detected in blood plasma (I54FI) and two had DRAMs in rectal secretions that was not detected in blood plasma (I47IM; K70N, L74I, Y115F, M184V, K103N, V108I, and H221Y).
HIV Reverse Transcriptase and Protease Genes Variability Can Be a Biomarker Associated with HIV and Hepatitis B or C Coinfection.
Result: Global sequence analysis showed that the most frequent amino
Discussion: In this study, this mutation was observed 32.3% of the time, and all patients with mutations were using 3TC, supporting the premise that the presence of M184V is due to the selective pressure of 3TC.
Discussion: Patient 91_co (HIV/HCV) has the codons T12S, L19I, L74V, K103R, E122K, D123E, I135T, S163C, M184V, L214F, K219E, E224K, V245M, L100I, V106I, V179D and M230L and used the drugs 3TC, EFV and TDF for treatment.
Discussion: The presence of M184V is related to early virologic failure during therapy with 3TC.
Discussion: This is useful because M184V reduces viral fitness.
HIV mutation literature information.
PMID: 
2018
Revista chilena de infectologia
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