Substitutions in the Reverse Transcriptase and Protease Genes of HIV-1 Subtype B in Untreated Individuals and Patients Treated With Antiretroviral Drugs.
PMID: 19825125
2005
Journal of the International AIDS Society
Abstract: Among mutations that confer resistance to antiretroviral drugs, M184V was present in 76% of treated patients and K70R in 31% (A-->G transitions).
Result: Among all ARV-treated patients, 76.4% harbored M184V and 31.3% harbored K70R, both of which result from a A G transition.
Table: M184V
Discussion: Of note, some of the common resistance mutations that are easily selected by drugs in vivo and in cell culture involve A G transitions, eg, M184V and Y181C.
Discussion: The G A hypermutation is the cause of the M184I substitution which commonly occurs prior to M184V.
Kinetics of Archived M184V Mutation in Treatment-Experienced Virally Suppressed HIV-Infected Patients.
PMID: 14551187
2004
The Journal of biological chemistry
Abstract: Additionally, we report how the decreased viral replication capacity of resistant viruses is directly linked to their decreased ability to use natural nucleotide substrates and that combination of the K65R and M184V resistance mutations leads to greater decreases in viral replication capacity.
Abstract: We report the molecular mechanisms by which a virus resistant to lamivudine with the M184V reverse transcriptase mutation shows increased susceptibility to tenofovir and can suppress the effects of the tenofovir resistance mutation K65R.
Relationships among various nucleoside resistance-conferring mutations in the reverse transcriptase of HIV-1.
PMID: 14645322
2004
The Journal of antimicrobial chemotherapy
Abstract: These resistant strains may often suffer from a replication disadvantage in comparison with wild-type viruses when grown in the absence of drug pressure and a potential benefit in this regard has been shown for lamivudine-resistant viruses that contain a M184V mutation in reverse transcriptase, as well as for several other drug-resistant viral variants.
Genotypic and phenotypic predictors of the magnitude of response to tenofovir disoproxil fumarate treatment in antiretroviral-experienced patients.
PMID: 14976601
2004
The Journal of infectious diseases
Abstract: Slightly increased treatment responses were observed when the M184V mutation was present.
Detection of drug-resistant minority variants of HIV-1 during virologic failure of indinavir, lamivudine, and zidovudine.
PMID: 14999613
2004
The Journal of infectious diseases
Abstract: The dominant week-40 82V-M184V clones had changes at protease codons 62-64, compared with all clones at week 24 and minority clones at week 40.
Investigating the effects of stereochemistry on incorporation and removal of 5-fluorocytidine analogs by mitochondrial DNA polymerase gamma: comparison of D- and L-D4FC-TP.
Abstract: While these results suggest that D-D4FC may present more mitochondrial toxicity than L-D4FC in cell-free assays, we have previously shown that HIV-1 RT prefers D-D4FC-TP as a substrate over the L-isomer, particularly in the case of mutant forms of RT associated with nucleoside drug resistance such as M184V.
Synthesis, structure-activity relationships, and mechanism of drug resistance of D- and L-beta-3'-fluoro-2',3'-unsaturated-4'-thionucleosides as anti-HIV agents.
PMID: 15027854
2004
Journal of medicinal chemistry
Abstract: However, L-3'F-4'Sd4C 34 and L-3'F-4'Sd4FC 35 showed high cross-resistance to 3TC-resistant mutant (M184V) RT.
Abstract: Like other unnatural L-nucleosides, the unfavorable steric hindrance of the sugar moiety of L-3'F-4'Sd4CTP with the side chain of Val184 explains its significant cross-resistance to the M184V mutant.
Genetic variation at NNRTI resistance-associated positions in patients infected with HIV-1 subtype C.
Abstract: The frequency of nucleoside associated mutations, but not M184V, in treated patients was significantly higher in subgroup B-infected patients (P = 0.028).
Mutations in HIV-1 reverse transcriptase potentially associated with hypersusceptibility to nonnucleoside reverse-transcriptase inhibitors: effect on response to efavirenz-based therapy in an urban observational cohort.
PMID: 15116307
2004
The Journal of infectious diseases
Abstract: CONCLUSIONS: The M41L, M184V, L210W, and T215Y mutations were associated with a better, although transient, virological outcome in patients treated with efavirenz-based regimens.
Abstract: RESULTS: The baseline RT mutations M41L, M184V, L210W, and T215Y and the M41L/T215Y and M41L/T215Y/M184V combinations were associated with virological suppression for efavirenz-treated patients, whereas, for PI-treated patients, only the M184V
Abstract: Similar to the M184V mutation, the K65R mutation is also associated with reduced in vitro viral replication capacity, hallmarks of which can be demonstrated at the enzymatic level.
HIV mutation literature information.
PMID: 
2005
Journal of the International AIDS Society
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