Abstract: By multiple stepwise logistic regression, factors associated with undetectable HIV RNA after 6 months of ART were: having M184V/I (odds ratio [OR] 0.11; 95% confidence interval [CI] 0.02-0.62, p = 0.013), condom use (OR 2.38; 95% CI 1.12-5.06, p = 0.024), and adherence per 5% increase (OR 1.16; 95% CI 1.00-1.35, p = 0.044).
Abstract: Fourteen major mutations of codon 99-191 on the RT gene were selected (K103N, V106A/M, V108I, Q151M, Y181C/I, M184V/I, Y188C/L/H, and G190S/A) at a cost of testing of 35 USD.
Abstract: The prevalence of each HIVDR mutation were PMID: 26831472
2016
The Lancet. Infectious diseases
Abstract: Of 700 individuals with tenofovir resistance, 578 (83%) had cytosine analogue resistance (M184V/I mutation), 543 (78%) had major NNRTI resistance, and 457 (65%) had both.
Method: Our secondary outcomes were resistance to first generation
Result: Furthermore, the M184V/I mutation was less common than NNRTI resistance across all regions except in eastern Africa.
Result: Prevalence of cytosine analogue resistance (M184V/I) was highest in sub-Saharan Africa and Latin America and lowest in western Europe.
Result: These results did not change when analysis was restricted to individuals who had evidence of the K65R mutation, either with or without M184V/I (appendix).
Time to Viremia for Patients Taking their First Antiretroviral Regimen and the Subsequent Resistance Profiles.
Abstract: One new NNRTI (Y181C) mutation was identified and three patients taking PI-based regimens developed NRTI mutations (M184 V, M184I, and T215Y).
Clinical Outcomes of Virologically-Suppressed Patients with Pre-existing HIV-1 Drug Resistance Mutations Switching to Rilpivirine/Emtricitabine/Tenofovir Disoproxil Fumarate in the SPIRIT Study.
Abstract: One patient with pre-existing Y181Y/C and M184I by proviral DNA genotyping experienced virologic failure.
Single Active Site Mutation Causes Serious Resistance of HIV Reverse Transcriptase to Lamivudine: Insight from Multiple Molecular Dynamics Simulations.
PMID: 26972300
2016
Cell biochemistry and biophysics
Abstract: Molecular dynamics simulations, binding free energy calculations, principle component analysis (PCA), and residue interaction network analysis were employed in order to investigate the molecular mechanism of M184I single mutation which played pivotal role in making the HIV-1 reverse transcriptase (RT) totally resistant to lamivudine.
HIV virological failure and drug resistance in a cohort of Tanzanian HIV-infected adults.
PMID: 27076106
2016
The Journal of antimicrobial chemotherapy
Abstract: Drug resistance mutations were present in 87/115 samples (75.7%); the most common were M184V/I (52.2%) and K103N (35%).
Rapid and Simultaneous Detection of Major Drug Resistance Mutations in Reverse Transcriptase Gene for HIV-1 CRF01_AE, CRF07_BC and Subtype B in China Using Sequenom MassARRAY(R) System.
Result: For NRTIs, the most common ADR-CRM were M184VI (76.0%) and T215YF (26.8%), whereas the most common SDRM were T215 revertants (2.4%) and M41L (2.0%) (Fig 1A).
Result: The frequency and patterns of mutations differed slightly among individuals under first-line ART schemes; however, in all cases higher percentages of M184VI, K103N and P225H were observed (Fig 3A, 3B and 3C).
Role of Rilpivirine and Etravirine in Efavirenz and Nevirapine-Based Regimens Failure in a Resource-Limited Country: A Cross- Sectional Study.
Method: RT-RAMs were identified and analyzed by using the Stanford Drug Resistance Database for V90I, A98G, L100I/V, K101E/P/Q/H/N, Result: Overall, the top 10 most common NNRTI-RAMs found in this study were V90I, followed by A98G, K101E, K103N, V108I, Y181C, M184I, Y188L, G190A and H221Y (Fig 1; listed according to the most frequently detected mutation to the least).
Rilpivirine and Doravirine Have Complementary Efficacies Against NNRTI-Resistant HIV-1 Mutants.
PMID: 27124362
2016
Journal of acquired immune deficiency syndromes (1999)
Introduction: In clinical trials that involved RPV and two NRTIs, the RT resistance mutations E138K and M184I/V were selected.
Result: Because many of the commonly used cART regimens include either 3TC or FTC, some isolates from virological failures also contained the M184V/I mutation.
Result: DOR potently inhibited the replication of E40K, K101E, V111A, M184I, M184V, K101E/M184I, K101E/M184V, E138K/M184I, an
HIV mutation literature information.
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2016
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