literature

HIV mutation literature information.

Assessing transmissibility of HIV-1 drug resistance mutations from treated and from drug-naive individuals.

PMID: 26355575 2015 AIDS (London, England)

Abstract: RESULTS: Prevalence of SDRMs in drug-naive and treatment-failing patients were linearly correlated, but some SDRMs were classified as outliers - above (PRO: D30N, N88D/S, L90 M, RT: G190A/S/E) or below (RT: M184I/V) expectations.

Result: For NRTIs, K219N and T215rev were consistently above, whereas K70E, Discussion: Our results are consistent with other studies: M184I/V has been shown to have low persistence after transmission to drug-naive patients; G190A has been shown to have high persistence.

Comparison of 454 Ultra-Deep Sequencing and Allele-Specific Real-Time PCR with Regard to the Detection of Emerging Drug-Resistant Minor HIV-1 Variants after Antiretroviral Prophylaxis for Vertical Transmission.

PMID: 26469189 2015 PloS one

Result: 28: M184I instead of M184V) (Table 3).

Result: Seven 3TC-selected mutations (K65R or M184I) were present in six samples at frequencies of 1.0% to 6.1% (Table 2).

Table: M184I

Virological Response and Antiretroviral Drug Resistance Emerging during Antiretroviral Therapy at Three Treatment Centers in Uganda.

PMID: 26700639 2015 PloS one

Abstract: Of the 35 patients with mutations at T2, 80% had M184V/I, 65.7% Y181C, and 48.6% (54.8% excluding those not on Tenofovir) had K65R mutations.

Result: Of the 35 patients with mutations at T2, 80% had M184V/I, 65.7% Y181C and 48.6% (54.8%, if those not on Tenofovir are excluded) had K65R mutations.

HIV-1 Drug Resistance Mutations: Potential Applications for Point-of-Care Genotypic Resistance Testing.

PMID: 26717411 2015 PloS one

Result: K70R, L74V/I, Y115F

Result: Fig 2 shows that in viruses from individuals in LMICs with intermediate or high-level NRTI resistance following VF on a first-line NRTI/NNRTI-containing regimen, the most common major DRMs were M184V (91.5%) and M184I (3.7%), K65R (9.8%), and the TAMs K70R (14.6%), T215Y (11.0%) and T215F (9.3%).

Week 96 analysis of rilpivirine or efavirenz in HIV-1-infected patients with baseline viral load

PMID: 23980523 2014 HIV medicine

Abstract: Among those with VFres , more patients in the rilpivirine group than in the efavirenz group developed N[t]RTI RAMs, mostly M184I/V.

Abstract: More patients with VFres in the rilpivirine group than in the efavirenz group developed N[t]RTI RAMs (mostly M184I/V).

Transmitted drug resistance is still low in newly diagnosed human immunodeficiency virus type 1 CRF06_cpx-infected patients in Estonia in 2010.

PMID: 24025024 2014 AIDS research and human retroviruses

Abstract: In 2010, 2.5% (6/244) of the sequences harbored nonnucleoside reverse transcriptase inhibitor (NNRTI) (K103N and K101E), 1.6% (4/244) nucleoside reverse transcriptase inhibitor (NRTI) (M41L, M184I, and K219E), and 0.4% (1/244) protease inhibitor (PI) (V82A) mutations.

Dried blood spots for HIV-1 drug resistance genotyping in decentralized settings in Senegal.

PMID: 24122937 2014 Journal of medical virology

Abstract: M184V/I was the most frequent mutation occurring, followed by K103N.

The connection domain mutation N348I in HIV-1 reverse transcriptase enhances resistance to etravirine and rilpivirine but restricts the emergence of the E138K resistance mutation by diminishing viral replication capacity.

PMID: 24227862 2014 Journal of virology

Abstract: Clinical resistance to rilpivirine (RPV), a novel nonnucleoside reverse transcriptase (RT) inhibitor (NNRTI), is associated an E-to-K mutation at position 138 (E138K) in RT together with an M184I/V mutation that confers resistance against emtricitabine (FTC), a nucleoside RT inhibitor (NRTI) that is given together with RPV in therapy.

Abstract: These two mutations can compensate for each other in regard to fitness deficits conferred by each mutation alone, raising the question of why E138K did not arise spontaneously in the clinic following lamivudine (3TC) use, which also selects for the M184I/V mutations.

Drug resistance mutations and genetic diversity in adults treated for HIV type 1 infection in Mauritania.

PMID: 24318486 2014 Journal of medical virology

Abstract: Overall, the most common DRMs detected were M184V/I (n = 32; 49.2%), K103N (n = 28; 43%), and Y181C (n = 13; 20%).

Differential impact of APOBEC3-driven mutagenesis on HIV evolution in diverse anatomical compartments.

PMID: 24401644 2014 AIDS (London, England)

Abstract: G73S in protease; M184I, M230I in reverse transcriptase) and two other patients' rectal tissues (M184I, M230I in reverse transcriptase) while such mutations were absent from paired peripheral blood mononuclear cells.

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