Result: According to the IAS-USA, the mutations associated with drug resistance, with a p >10%, were L10I, M36I, I62V, L63P, I64V, A71V/T, V77I, L90M, and I93L.
Result: Codon 90 contained a drug resistance mutation (L90M) common for most PIs, with the exception of DRV and TPV, while T91 and Q92 contained the T91V, Q92G, and Q92K mutations, which are classified in the literature as unusual mutations.
Result: The prevalence of the L90M, T91
Effects of PRE and POST therapy drug-pressure selected mutations on HIV-1 protease conformational sampling.
Result: L90M may also participate in subtle changes in hydrophobic packing of this region.
Result: Although PR20 does not show a predominant closed flap orientation in the absence of inhibitor, this construct also contains the following mutations considered to be within the hydrophobic core: L10F/I13V/I15V/I33F/M36I/-I62V/L90M.
Systematic molecular dynamics, MM-PBSA, and ab initio approaches to the saquinavir resistance mechanism in HIV-1 PR due to 11 double and multiple mutations.
PMID: 25036111
2014
The journal of physical chemistry. B
Abstract: Furthermore, it was observed that mutation accumulation may induce stabilization to SQV and to the flaps through enhanced HB interactions that lead to improved inhibition (e.g., accumulation of mutations in complexes containing L10I, G48V, L63P, I84V, or L90M single mutations).
Abstract: Herein, we extend our analysis, which includes seven double (G48V-V82A, L10I-G48V, G48V-L90M, I84V-L90M, L10I-V82A, L10I-L6
Increase in transmitted resistance to non-nucleoside reverse transcriptase inhibitors among newly diagnosed HIV-1 infections in Europe.
Result: Of the 243 patients who received one or more protease inhibitors, 32 (13%) had a study-defined protease inhibitor-resistance mutation most commonly L10F, K20T, V32I, L33F, M46I/L, I47V/A, I50L, F53L, I54V/L, Q58E, L76V, V82A/C, I84V, L89V, and L90M.
A significant reduction in the frequency of HIV-1 drug resistance in Quebec from 2001 to 2011 is associated with a decrease in the monitored viral load.
Result: The most common primary mutations associated with ARV resistance in TE individuals ( Figure 2 ) were NRTIs: M184I/V (51.1%) and thymidine analog mutations (TAM) from TAM1 pathway (41L/210W/215Y; 17%), representing 76.2% of all TAM pathways (data not shown); NNRTIs: K103N (24.9%); PIs: L90 M (21.1%), V82 (16.8%), M46I/L (18.2%).
Minority drug-resistant HIV-1 variants in treatment naive East-African and Caucasian patients detected by allele-specific real-time PCR.
Result: Direct sequencing identified additional TDR in two patients: T215S and L90M, respectively.
Table: L90M
Transmitted antiretroviral drug resistance mutations in newly diagnosed HIV-1 positive patients in Turkey.
PMID: 25397495
2014
Journal of the International AIDS Society
Abstract: RESULTS: The patients had TDRMs to NRTIs (K65R, M184V), NNRTIs (K101E, K103N/S, G190A/E/S, Y181I/C, Y188H/L) and PIs (M46L, I54V, L76V, V82L/T, N83D, I84V, L90M).
Use of dolutegravir in two INI-experienced patients with multiclass resistance resulted in excellent virological and immunological responses.
PMID: 25397500
2014
Journal of the International AIDS Society
HIV mutation literature information.
PMID: 
2014
BMC bioinformatics
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