An in silico pharmacological approach toward the discovery of potent inhibitors to combat drug resistance HIV-1 protease variants.
PMID: 30506751
2019
Journal of cellular biochemistry
Abstract: Herein, we strive for compounds that can stifle the function of wild-type (WT) HIV-1 PR along with four major single mutants (I54M, V82T, I84V, and L90M) instigating resistance to the PIs using in silico approach.
Sexual intermingling of Arab and Jewish MSM in Israel: results of a molecular epidemiology study.
Abstract: Overall, 13.1% (66/502) had TDRM; reverse transcriptase-K103N/S, M184 V, T215S and protease-L90M were the most common.
Abstract: Phylogenetic analysis demonstrated AMSM and JMSM clusters including L90M, K103N/S or T215S TDRM.
Trends in the Molecular Epidemiology and Genetic Mechanisms of Transmitted Human Immunodeficiency Virus Type 1 Drug Resistance in a Large US Clinic Population.
Result: Figure 5 contains a time-scaled Bayesian phylogenetic tree that illustrates in red the likely origin of the cluster of 12 viruses containing the NNRTI DRM Y181C plus the PI DRM L90M.
Result: Of the 203 PI-associated SDRMs, the most common were L90M (33.5%), M46I/L (19.7%), I54V (10.8%), V82A/L/T (10.4%), and D30N plus N88D (9.8%).
Figure: One individual (PID 50) was also primarily infected with this virus as a 2002 sequence obtained prior to therapy contained Y181C +
Consistent Prediction of Mutation Effect on Drug Binding in HIV-1 Protease Using Alchemical Calculations.
PMID: 29847122
2018
Journal of chemical theory and computation
Abstract: In this study, we analyze ten different protease-inhibitor complexes carrying major resistance-associated mutations (RAMs) G48V, I50V, and L90M using molecular dynamics simulations.
Next generation sequencing of HIV-1 protease in the PIVOT trial of protease inhibitor monotherapy.
Introduction: In two other patients, both of whom received darunavir monotherapy and had no prior PI exposure, L90M was the sole protease mutation detected; this is rarely selected de novo by darunavir and is a relatively common transmitted mutation.
[Genetic analysis of the mutations in HIV-1 infected population in Ecuador].
PMID: 29652972
2018
Revista chilena de infectologia
Abstract: Results The most frequent mutations were M184V/I, K101E/P/H, K103N/S, D30N, M46L/I, I54L/M, V82T/F/A/S/L and L90M in adults and F77L, K103N/S, M46L/I, V82T/F/A/S/L and L90M in children.
Changes from 2000 to 2009 in the Prevalence of HIV-1 Containing Drug Resistance-Associated Mutations from Antiretroviral Therapy-Naive, HIV-1-Infected Patients in the United States.
PMID: 29732898
2018
AIDS research and human retroviruses
Abstract: The most frequently detected IAS-USA-defined DRMs by class were NNRTI: K103N/S (4%), NRTI: M41L (1.5%), and PI: L90M (1%).
Result: The prevalence of major PI mutations was 3% [95% CI (2.6%-3.8%)], and the most prevalent PI mutation was L90M [1%, 95% CI (0.7%-1.4%)].
Result: The prevalence of major PI mutations was 3%, 95% CI: 2.8%-4.0%, while the most prevalent PI mutation was L90M [1%, 95% CI (0.8%-1.5%)].
HIV Reverse Transcriptase and Protease Genes Variability Can Be a Biomarker Associated with HIV and Hepatitis B or C Coinfection.
Result: The major mutations to PI were I54V (2.9%), V82A (11.7%), M46I (8.8%) and L90M (40.4%).
Ultra-deep sequencing improves the detection of drug resistance in cellular DNA from HIV-infected patients on ART with suppressed viraemia.
PMID: 30137335
2018
The Journal of antimicrobial chemotherapy
Abstract: However, the detection of RAMs by UDS with a 1% cut-off was significantly higher than that of bulk sequencing for RT codons D67N (65.4% versus 52.3%), M184V (66.2% versus 52.3%), L210W (48.9% versus 36.4%) and T215Y (57.9% versus 42.1%) and PR codons M46I (46% versus 26%), I54L (12.4% versus 3.9%), V82A (44.5% versus 29.9%) and L90M (57.7% versus 42.5%).
Drug Resistance Mutation L76V Alters Nonpolar Interactions at the Flap-Core Interface of HIV-1 Protease.
Discussion: Mutation L76V is not unusual in this respect; mutations L90M and N88D/S also have no direct interactions with inhibitors, yet are strongly associated with resistance to one or more clinical inhibitors.
HIV mutation literature information.
PMID: 
2019
Journal of cellular biochemistry
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