literature

HIV mutation literature information.

Diversity of HIV-1 Subtypes and Transmitted Drug-resistance Mutations Among Minority HIV-1 Variants in a Turkish Cohort.

PMID: 34802406 2022 Current HIV research

Abstract: M41L, L74I, K65R, M184V, and M184I related to NRTI, K103N to NNRTI, and N83D, M46I, I84V, V82A, L24I, L90M, I54V to the PI sites were identified using NGS.

Rising rates of recent preexposure prophylaxis exposure among men having sex with men newly diagnosed with HIV: antiviral resistance patterns and treatment outcomes.

PMID: 34873084 2022 AIDS (London, England)

Table: L90M

Brief Report: Bictegravir/Emtricitabine/Tenofovir Alafenamide Efficacy in Participants With Preexisting Primary Integrase Inhibitor Resistance Through 48 Weeks of Phase 3 Clinical Trials.

PMID: 34897227 2022 Journal of acquired immune deficiency syndromes (1999)

Table: L90M

Trends of Transmitted and Acquired Drug Resistance in Europe From 1981 to 2019: A Comparison Between the Populations of Late Presenters and Non-late Presenters.

PMID: 35495657 2022 Frontiers in microbiology

Abstract: The most prevalent TDR drug resistance mutations, in both LP and NLP, were K103N/S, T215rev, T215FY, M184I/V, M41I/L, M46I/L, and L90M.

Prevalence of HIV-1 drug resistance in Eastern European and Central Asian countries.

PMID: 35061671 2022 PloS one

Discussion: The most frequent PI DRMs included M46I and L90M, which are associated with DR to nelfinavir, which was not considered for PDR estimation and has not been used since 2013; additionally, N88D and L10F only minimally reduce susceptibility to drugs.

Detection of Gag C-terminal mutations among HIV-1 non-B subtypes in a subset of Cameroonian patients.

PMID: 35082353 2022 Scientific reports

Result: In Class I, two mutations were positively correlated (phi > 0, p < 0.001) as pairs with protease major resistance mutations: L449F correlated with the major resistance mutations V32I (phi = 0.38, p = 0.008), I54V (phi = 0.27, p = 0.015) and L90M (phi = 0.32, p = 0.015); Discussion: Protease mutation L90M had the strongest correlation with L449F which is confirmed in the dendrogram.

Discussion: These major protease mutations I50V and L90M would therefore be a sentinel for the L449F in the Gag gene.

HIV Pretreatment Drug Resistance Trends in Mexico City, 2017-2020.

PMID: 34959542 2021 Pathogens (Basel, Switzerland)

Result: Other interesting clusters evidencing PDR transmission within the network included cluster PI-1, with 29 nodes, all men with PI resistance and median age 24 (22-28) enrolled across all years; cluster NRTI-1, with 23 nodes, 22 cisgender men and 1 cisgender woman, with median age 22 (10-27) and constant growth across all years; cluster complex-1, with 10 nodes, all men enrolled from 2018 to 2020 and median age 23 (20-30), 60% (6/10) with PI + NRTI + NNRTI resistance and 40% (4/10) with PI + NRTI resistance; and complex-2, with 7 nodes, all men with median age 26 (21-31) sharing PR M46I, L90M,

Correlation of HIV-1 drug resistant mutations and virologic failure.

PMID: 34584606 2021 The Pan African medical journal

Introduction: These mutations included M184V, K65R,D67N,K70R,K219Q,Q151M, T215F, M41L, T69N, V75M, M41L, T69N, V75M, D67G, V75M, M184I, T215N, M41LM, T215N, K219N,210W, T215Y as NRTIs; K103N/S

Molecular Network Analysis Reveals Transmission of HIV-1 Drug-Resistant Strains Among Newly Diagnosed HIV-1 Infections in a Moderately HIV Endemic City in China.

PMID: 35069498 2021 Frontiers in microbiology

Discussion: Only I54L (n = 1), V82A (n = 1), and L90M (n = 5) conferred low or intermediate resistance to LPV/r, suggesting that the low prevalence of these TDRs is related to the fact that LPV/r is not widely used as a second-line drug in China.

HIV-1 drug resistance among individuals who seroconverted in the ASPIRE dapivirine ring trial.

PMID: 34762770 2021 Journal of the International AIDS Society

Result: One sample had the L90M protease inhibitor resistance mutation with no other NRTI or NNRTI mutations.

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