literature

HIV mutation literature information.

Transmitted drug resistance and transmission clusters among HIV-1 treatment-naive patients in Guangdong, China: a cross-sectional study.

PMID: 34488793 2021 Virology journal

Discussion: The most frequent PI-associated mutation in our study was M46L, whereas it is Q56E in southwest China, M46I in Iceland, and L90M in the south-central United States.

High Detection Rate of HIV Drug Resistance Mutations among Patients Who Fail Combined Antiretroviral Therapy in Manaus, Brazil.

PMID: 34212033 2021 BioMed research international

Result: Only half of the individuals had used PI (n = 46/82), only 17% of individuals presented DRMs associated with protease inhibitors (n = 14), and the most frequent mutations were V82A/L/M (6/82; 7.3%) and I54L/M/V (5/82; 6%), L90M (4/82; 4.8%), and M46L/I (4/82; 4.8%) (Figure 1).

Reverse transcriptase and protease inhibitors mutational viral load in HIV infected pregnant women with transmitted drug resistance in Argentina.

PMID: 34085506 2021 Revista espanola de quimioterapia

Abstract: Most frequent PI-RAMs were I85V, M46I, I50V and L90M (n=2, 5% each).

Result: Most frequent PI-RAMS were I85V, M46I, I50V and L90M (n=2, 5% each), all of them with modest impact in the activity of currently available PIs.

Nationwide Study of Drug Resistance Mutations in HIV-1 Infected Individuals under Antiretroviral Therapy in Brazil.

PMID: 34069929 2021 International journal of molecular sciences

Result: The SDRM with most similar prevalence when comparing both groups were M46I, V82A, L90M and I54V.

Acquired HIV-1 Protease Conformational Flexibility Associated with Lopinavir Failure May Shape the Outcome of Darunavir Therapy after Antiretroviral Therapy Switch.

PMID: 33805099 2021 Biomolecules

Introduction: The major PI mutations are M46I and I54V found in the flap region, L76V located in the central beta-sheet that forms one of the active site's borders, the V82A mutation, which is found in the active site; and the L90M and L33F mutations in the HIV-1 PR hydrophobic core.

Discussion: A comparative analysis of the genotypic variation in the HIV-1 PR from subtype B and C from laboratory-generated sequences and publicly available database showed the L90M occur more in HIV-1 subtype B PR than HIV-1 PR variants from subtype C.

Discussion: The

Transmitted HIV-1 drug resistance in a large international cohort using next-generation sequencing: results from the Strategic Timing of Antiretroviral Treatment (START) study.

PMID: 33369017 2021 HIV medicine

Discussion: However, mutations like the RT K103NS, the T215 revertants and the PI L90M appear to have little effect on viral fitness and may persist for prolonged periods in individ

Discussion: Within the PI-related DRMs, the same picture emerged, with M46IL and D30N predominately seen as minor variants, whereas L90M (associated with saquinavir resistance), if present, dominated the quasispecies.

Discussion: study, a similar pattern was observed, with the M46IL and D30N detected predominately as minor variants while the majority of L90M mutations occurred above the 20% threshold.

High prevalence of integrase mutation L74I in West African HIV-1 subtypes prior to integrase inhibitor treatment.

PMID: 32105319 2020 The Journal of antimicrobial chemotherapy

Table: L90M

Pretreatment HIV drug resistance spread within transmission clusters in Mexico City.

PMID: 31819984 2020 The Journal of antimicrobial chemotherapy

Result: The most frequent PI mutations included M46I/L and L90M.

Highly drug-resistant HIV-1 protease reveals decreased intra-subunit interactions due to clusters of mutations.

PMID: 31920003 2020 The FEBS journal

Result: Another study on single mutants V32I, L33F, L76V, and L90M showed how remote mutations can impact inhibitor binding by altering protein ensemble dynamics through a rearranged network of residues circulating to the active site.

Trend of HIV-1 drug resistance in China: A systematic review and meta-analysis of data accumulated over 17 years (2001-2017).

PMID: 31922125 2020 EClinicalMedicine

Result: Four mutations T69D (NRTI), K103N/S (NNRTI), M46I/L (PI) and L90M (PI) showed significantly different percentages in different subtypes (p < 0.05) (Table 1).

Table: L90M

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