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 HIV mutation literature information.


  Functional characteristics of the natural polymorphisms of HIV-1 gp41 in HIV-1 isolates from enfuvirtide-naive Korean patients.
 PMID: 26997611       2016       Archives of virology
Abstract: Moreover, most point mutants showed lower IC50 values for enfuvirtide than the wild type, whereas the L7M substitution resulted in a slightly increased IC50 value.


  Characterization of Gp41 polymorphisms in the fusion peptide domain and T-20 (Enfuvirtide) resistance-associated regions in Korean HIV-1 isolates.
 PMID: 24616600       2014       Journal of Korean medical science
Abstract: This study of gp41 polymorphisms showed that insertions in the fourth threonine (74.8%) and L7M substitutions (85.3%) were more frequent in the fusion peptide motif in Korean HIV-1 isolates compared with those from other countries.
Introduction: In addition, many of the FPs in Korean HIV-1 isolates had L7M substitutions near the FLGFL motif.
Introduction: Table 1 shows that the dominant mutation was a T-insertion mutation (n=122, 74.8%), while an L7M substitution near the FLGFL motif was also frequent in HIV-1-infected patients (n=139, 85.3%).



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