Result: UDPS revealed a virus harboring 2 major DRMs: L74 V at minority-level (2.5%), causing high- and intermediate-level resistance respectively to didanosine and to ABC; Y181C at population-level (96.7%), causing high- and intermediate-level resistance respectively to NVP and to EFV, ETR, and RPV (Table 3).
HIV Reverse Transcriptase and Protease Genes Variability Can Be a Biomarker Associated with HIV and Hepatitis B or C Coinfection.
Discussion: Patient 91_co (HIV/HCV) has the codons T12S, L19I, L74V, K103R, E122K, D123E, I135T, S163C, M184V, L214F, K219E, E224K, V245M, L100I, V106I, V179D and M230L and used the drugs 3TC, EFV and TDF for treatment.
Emergence of HIV-1 drug resistance mutations in mothers on treatment with a history of prophylaxis in Ghana.
Result: The major drug resistance associated mutations to NRTIs seen among the Group 1 participants were M41 L, M184 V, M184MV, L74 V and T215Y with no minor drug resistant associated mutations to NRTIs in this group.
High prevalence of HIV-1 transmitted drug resistance among therapy-naive Burmese entering travelers at Dehong ports in Yunnan, China.
Abstract: The HIV genotype revealed Met184Val, Leu7
Result: Genotypic testing (GenoSure MG) for the HIV strain isolated from this patient showed notable RT mutations of L74V, L100I, M184V, and K103N, none of which are known to confer resistance to TDF, although M184V confers high-level resistance to FTC.
Result: SGS was consistent with the standard genotype in detecting RT mutations: specifically L74V, L100I, M184V, and K103N were detected, but K65R and K70E were not.
Fidelity of classwide-resistant HIV-2 reverse transcriptase and differential contribution of K65R to the accuracy of HIV-1 and HIV-2 reverse transcriptases.
Introduction: L74V, E89G, V111I, S215Y, L74V/S215Y and E89G/S215Y), whose effects were evaluated for a small subset of misincorporations or mispairs using nucleotide discrimination assays.
High Prevalence of Abacavir-associated L74V/I Mutations in Kenyan Children Failing Antiretroviral Therapy.
PMID: 28383390
2017
The Pediatric infectious disease journal
Result: All 37 children with L74V/I mutations also had M184V and thus high-level resistance to ABC from this combination of mutations.
Result: Detection of L74V/I was associated with ABC use (P < 0.001, 2-tailed Fisher's exact test) compared with those not on ABC (Table 1), but was not associated with the concurrent use of nevirapine , efavirenz or lopinavir/ritonavir (P = 0.34, P = 0.24 and P = 1.00, respectively, 2-tailed Fisher's exact test).
Result: Of the 121 children on any regimens with DRMs, 37 (31%) harbored L74V/I mutations with 35 (95%) being on ABC-containing regimens at the time of sample collection; for 32 of these children, ABC was part of their original ART regimens.
Result: Of the 35 children on ABC with L74V/I mutations, 30 had L74V,
HIV-1 drug-resistant mutations and related risk factors among HIV-1-positive individuals experiencing treatment failure in Hebei Province, China.
Result: For example, M41L and D67N had 16 (D218E, E44A, G190S, G196E, H221Y, I142V, K101E, L210W, L228R, L74V, M184V, R211K, T215F, V108I, V118I, and V179I) and nine (E44A, H208Y, H221Y, K70R, L210W
HIV mutation literature information.
PMID: 
2018
PLoS medicine
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