Epidemiological Surveillance of HIV-1 Transmitted Drug Resistance in Spain in 2004-2012: Relevance of Transmission Clusters in the Propagation of Resistance Mutations.
Result: It is noteworthy that several major mutations associated to high level resistance to NRTIs (K65R, L74V, Y115F, M184V and T215Y), to NNRTIs (l100I, K101E, K103N/S, V106M, Y181C, Y188L and G190A) and to PIs (D30N, M46I/L, I54V/T, L76V, V82A, I84V, N88D
Prevention of mother-to-child HIV-1 transmission in Burkina Faso: evaluation of vertical transmission by PCR, molecular characterization of subtypes and determination of antiretroviral drugs resistance.
Single Genome Analysis for the Detection of Linked Multiclass Drug Resistance Mutations in HIV-1-Infected Children After Failure of Protease Inhibitor-Based First-Line Therapy.
PMID: 25923117
2015
Journal of acquired immune deficiency syndromes (1999)
5Result: More than 1 RT DRM linked on the same genome were detected in 2 children: in ""J,"" Y181C was linked with V106M (2%, n = 49 sequences) and K219N (2%); in ""E,"" Y181C linked with the accessory TAM, K219N, was detected (3%, n = 30 sequences) and linked dual-class resistance (Y181C with L74V) was also detected (7%) in the baseline viral population of this child."
Change in the Prevalence of HIV-1 and the Rate of Transmitted Drug-Resistant HIV-1 in Haiphong, Northern Vietnam.
PMID: 25970090
2015
AIDS research and human retroviruses
Abstract: Nonnucleoside RT inhibitor-resistant mutations, Y181C/I, were detected in three subjects; one had the nucleoside RT inhibitor-resistant mutations L74V and M184V and one had E138K.
Effectiveness of a Treatment Switch to Nevirapine plus Tenofovir and Emtricitabine (or Lamivudine) in Adults with HIV-1 Suppressed Viremia.
Result: The 22 cases experiencing virologic failure presented with the following DRMs: M46I, F53LY, I54LTV, G73ST, L76V, V82AT, I84V, I185V, N88D, and L90M for PIs; L100I, K103NS, V179F Y181C, G190AS, V106A, K103N, and P225H for NNRTIs; and
Assessing transmissibility of HIV-1 drug resistance mutations from treated and from drug-naive individuals.
Result: Mutations M41L (above) and L74I/V (below) were outside the CI for Portugal but not for DE, and T69N (above) and K65R (below) were outside the CI for DE but not for Portugal.
Discussion: We show here that D30N, N88D/S and L90 M also have high transmissibility and that other SDRMs have higher (M41L, T215Rev and K219E/N/Q/R for NRTIs and K101E/P for the NNRTIs) or lower transmissibility (K70E/R, L74I/V, and T215Y/F f
HIV-1 Drug Resistance Mutations: Potential Applications for Point-of-Care Genotypic Resistance Testing.
Result: K70R, L74V/I, Y115F, M184I, and T215Y/F were the most common major non-tier 1 DRMs associated with ADR on a first-line NRTI/NNRTI-containing regimen and with TDR.
Result: M184I, K65R, Result: L74V/I rarely occurred in the absence of M184V.
Result: Indeed, among both adults and children receiving ABC, L74V/I were the second most common major NRTI DRMs associated with acquired NRTI resistance after M184V.
HIV Drug Resistance Surveillance in Honduras after a Decade of Widespread Antiretroviral Therapy.
Method: In this study, HIV-2 resistance mutations were identified using the list generated by the 'Collaborative HIV and Anti-HIV Drug Resistance Network', leading to the following mutations in reverse transcriptase - K65R, D67G/N, N69S/T, K70N/R, L74V, V111I, Y115F, M184I/V, Q151M, S215A/C/F/L/Y, K223R; and in protease - V47A, G48V, I50V, I54L/M,
HIV mutation literature information.
PMID: 
2015
PloS one
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