literature

HIV mutation literature information.

The base component of 3'-azido-2',3'-dideoxynucleosides influences resistance mutations selected in HIV-1 reverse transcriptase.

PMID: 21646480 2011 Antimicrobial agents and chemotherapy

Abstract: Population sequencing of the entire reverse transcriptase (RT) gene identified L74V, F77L, and L214F mutations in the polymerase domain and K476N and V518I mutations in the RNase H domain.

Abstract: Single-genome sequencing analyses of the selected virus revealed a complex population of mutants that all contained L74V and L214F linked to other mutations, including ones not identified during population sequencing.

Subunit-specific mutational analysis of residue N348 in HIV-1 reverse transcriptase.

PMID: 21859446 2011 Retrovirology

Introduction: Furthermore, N348I can compensate for the antagonism of thymidine analog mutations (TAMs) by the L74V, Y181C or M184V mutations.

Resistance patterns selected by nevirapine vs. efavirenz in HIV-infected patients failing first-line antiretroviral treatment: a bayesian analysis.

PMID: 22132100 2011 PloS one

Method: RT mutations were identified from the International AIDS Society USA Drug (IAS-USA) mutation tables, spring 2008 (http://www.iasusa.org/resistance_mutations): M41L, K65R, D67N, insertion 69, K70R/E, L74I/V, L100I, K103N, V106A/M, V108I, Q151M, Y181I/C, M184V, Y188C/L, G190A/S, L210W, T215Y/F,

PMID: 22180722 2011 Romanian biotechnological letters

Result: 19.5% of the patients presented L74V/I mutation that occur in patients with virologic failure while receiving non-TAM regimens and causes intermediate resistance to DDI and ABC, and a slight increase in susceptibility to AZT and TDF.

Resistance profile of the new nucleoside reverse transcriptase inhibitor apricitabine.

PMID: 20007333 2010 The Journal of antimicrobial chemotherapy

Abstract: Apricitabine shows antiviral activity in vitro against HIV-1 strains and clinical isolates with mutations in the reverse transcriptase that confer resistance to other NRTIs, including M184V, thymidine analogue mutations (TAMs), nucleoside-associated mutations such as L74V and certain mutations at codon 69.

N348I in reverse transcriptase provides a genetic pathway for HIV-1 to select thymidine analogue mutations and mutations antagonistic to thymidine analogue mutations.

PMID: 20160634 2010 AIDS (London, England)

Method: The K70R, L74V, Y181C, M184V and N348I mutations were introduced into the wild-type (WT) p6HRT-Prot prokaryotic expression vector by site-directed mutagenesis using the QuikChange mutagenesis kit (Stratagene La Jolla, CA).

Method: The WT, K70R, Y181C, N348I, K70R/Y181C, K70R/Y181C/N348I, K70R/L74V, K70R/L74V/N348I,

Antiviral activity and tolerability of amdoxovir with zidovudine in a randomized double-blind placebo-controlled study in HIV-1-infected individuals.

PMID: 20386073 2010 Antiviral therapy

Introduction: As observed for the K65R variant, virus containing the L74V mutation remained sensitive to zidovudine.

Introduction: Selection studies showed a delayed emergence of HIV-1-resistant viruses to DXG, which was associated with K65R or L74V mutations in MT-2 cells.

The non-nucleoside reverse transcriptase inhibitor efavirenz stimulates replication of human immunodeficiency virus type 1 harboring certain non-nucleoside resistance mutations.

PMID: 20399480 2010 Virology

Abstract: Addition of the nucleoside resistance mutations L74V or M41L+T215Y to K101E+G190S improved fitness and abolished EFV-dependent stimulation of replication.

Introduction: One example of this type of mutation is L74V, which confers resistance to the nucleoside analogs abacavir and didanosine and improves the replication fitness of the NNRTI-resistant mutants G190E and K103N+L100I.

Method: Mutagenic primers were as follows: L74V, 5'-CAG TAC TAA ATG GAG AAA AGT AGT AGA TTT CAG AGA AC3' (forward) and 5' GTT CTC TGA AAT CTA CTA CTT TTC TCC ATT TAG TAC TG 3' (r

Constrained patterns of covariation and clustering of HIV-1 non-nucleoside reverse transcriptase inhibitor resistance mutations.

PMID: 20462946 2010 The Journal of antimicrobial chemotherapy

Method: We also examined the extent to which the 52 NNRTI-selected mutations covaried with mutations at 12 major nucleoside reverse transcriptase inhibitor (NRTI) resistance positions, including M41L, K65R, D67N, T69S_SS, K70E, K70R, L74V, L74I, V75M/T, Y115F, Q151M, M184V/I, L210W, T215F and T215Y.

Result: The strongest positive correlations were bet

Synthesis and anti-HIV activity of 2'-deoxy-2'-fluoro-4'-C-ethynyl nucleoside analogs.

PMID: 20542430 2010 Bioorganic & medicinal chemistry letters

Table: L74V

Browser Board

Co-occurred Entities

Filtrator