literature

HIV mutation literature information.

Lys66 residue as a determinant of high mismatch extension and misinsertion rates of HIV-1 reverse transcriptase.

PMID: 22925131 2012 The FEBS journal

Introduction: Leu74Val mutations have shown up to a 6-fold reduction in misinsertion frequency, and a 15-26-fold reduction in mismatch extension frequency.

HIV-1 drug resistance genotyping from antiretroviral therapy (ART) naive and first-line treatment failures in Djiboutian patients.

PMID: 23044036 2012 Diagnostic pathology

Table: L74V

Low prevalence of transmitted K65R and other tenofovir resistance mutations across different HIV-1 subtypes: implications for pre-exposure prophylaxis.

PMID: 23305651 2012 Journal of the International AIDS Society

Discussion: Though uncommon and despite in vitro antagonism, K65R occurred with other mutations that impact viral fitness, including M184V in 35% (7/20) and L74V in 5% (1/20) of K65R-containing sequences.

High rate of K65R for antiretroviral therapy-naive patients with subtype C HIV infection failing a tenofovir-containing first-line regimen.

PMID: 22739389 2012 AIDS (London, England)

Discussion: However, mutations found in combination with K65R in our study either have a minor effect on susceptibility to AZT or enhance susceptibility to AZT (eg.L74V, Y181C, M184V as well as K65R).

HIV-1 drug resistance at antiretroviral treatment initiation in children previously exposed to single-dose nevirapine.

PMID: 21633285 2011 AIDS (London, England)

Result: Nineteen samples had major NRTI mutations, specifically K219E/Q (n=8), L74V (n=7), K70E (n=3), D67N (n=2) and L210W (n=1).

The base component of 3'-azido-2',3'-dideoxynucleosides influences resistance mutations selected in HIV-1 reverse transcriptase.

PMID: 21646480 2011 Antimicrobial agents and chemotherapy

Abstract: Population sequencing of the entire reverse transcriptase (RT) gene identified L74V, F77L, and L214F mutations in the polymerase domain and K476N and V518I mutations in the RNase H domain.

Abstract: Single-genome sequencing analyses of the selected virus revealed a complex population of mutants that all contained L74V and L214F linked to other mutations, including ones not identified during population sequencing.

Subunit-specific mutational analysis of residue N348 in HIV-1 reverse transcriptase.

PMID: 21859446 2011 Retrovirology

Introduction: Furthermore, N348I can compensate for the antagonism of thymidine analog mutations (TAMs) by the L74V, Y181C or M184V mutations.

Differences in reversion of resistance mutations to wild-type under structured treatment interruption and related increase in replication capacity.

PMID: 21297946 2011 PloS one

Method: The final list of mutations included M41L, E44D, D67N, T69D, K70R, L74V, L100I, K103N, V108I, V118I, Y181C, M184V, G190A, L210W, T215F, T215Y and K219Q in RT; and L33F, L33I, M46I, M46L, G48V, <

Resistance patterns selected by nevirapine vs. efavirenz in HIV-infected patients failing first-line antiretroviral treatment: a bayesian analysis.

PMID: 22132100 2011 PloS one

Method: RT mutations were identified from the International AIDS Society USA Drug (IAS-USA) mutation tables, spring 2008 (http://www.iasusa.org/resistance_mutations): M41L, K65R, D67N, insertion 69, K70R/E, L74I/V, L100I, K103N, V106A/M, V108I, Q151M, Y181I/C, M184V, Y188C/L, G190A/S, L210W, T215Y/F,

PMID: 22180722 2011 Romanian biotechnological letters

Result: 19.5% of the patients presented L74V/I mutation that occur in patients with virologic failure while receiving non-TAM regimens and causes intermediate resistance to DDI and ABC, and a slight increase in susceptibility to AZT and TDF.

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