literature

HIV mutation literature information.

Clonal analyses of HIV quasispecies in patients harbouring plasma genotype with K65R mutation associated with thymidine analogue mutations or L74V substitution.

PMID: 15802984 2005 AIDS (London, England)

Abstract: We analysed the quasispecies at a clonal level in patients whose plasma genotypic test harboured K65R with L74V or thymidine analogue mutations (TAM).

Abstract: We found no clone bearing both K65R and L74V substitutions.

Clinically relevant genotype interpretation of resistance to didanosine.

PMID: 15855490 2005 Antimicrobial agents and chemotherapy

Abstract: Eight mutations were associated with a reduced response to ddI, M41L, D67N, T69D, L74V, V118I, L210W, T215Y/F, and K219Q/E, and two mutations were associated with a better response, K70R and M184V/I.

Abstract: The best prediction of the virologic response to ddI was obtained with a composite score comprising mutations added and subtracted (set II, M41L + T69D + L74V+ T215Y/F + K219Q/E - K70R -

Mechanism of anti-human immunodeficiency virus activity of beta-D-6-cyclopropylamino-2',3'-didehydro-2',3'-dideoxyguanosine.

PMID: 15855524 2005 Antimicrobial agents and chemotherapy

Abstract: Mutations of leucine 74 to valine and of lysine 65 to arginine had mild to moderate resistance (as high as fivefold).

Resistance mutations before and after tenofovir regimen failure in HIV-1 infected patients.

PMID: 15902696 2005 Journal of medical virology

Abstract: In addition, five genotypes harboring K65R with TAMs or L74V mutation were observed at failure.

Abstract: The K65R mutation can emerge even with TAMs or L74V.

[Efficacy of anti-HIV treatment and drug-resistance mutations in some parts of China].

PMID: 15949383 2005 Zhonghua yi xue za zhi

Abstract: In addition, intermediate level and low level resistance against NRTIs caused by K65R and L74V can also be found, but less commonly.

The L74V mutation in human immunodeficiency virus type 1 reverse transcriptase counteracts enhanced excision of zidovudine monophosphate associated with thymidine analog resistance mutations.

PMID: 15980332 2005 Antimicrobial agents and chemotherapy

Abstract: By contrast, the L74V mutation, which confers resistance to didanosine, sensitizes HIV-1 to AZT and partially restores AZT susceptibility when present together with one or more TAMs.

Abstract: These results demonstrate that L74V enhances AZT susceptibility by reducing the extent of its removal by ATP-dependent phosphorolysis and provides further evidence for a common mechanism by which mutations conferring resistance to didanosine and lamivudine sensitize HIV-1 to AZT.

Abstract: To compare rates of primer unblocking in RTs carrying different clusters of TAMs and to explore the biochemical mechanism by which L74V affects AZT susceptibility, ATP-mediated rescue of AZT-blocked DNA synthesis was assayed using a series of purified recombinant RTs.

Impaired rescue of chain-terminated DNA synthesis associated with the L74V mutation in human immunodeficiency virus type 1 reverse transcriptase.

PMID: 15980333 2005 Antimicrobial agents and chemotherapy

Abstract: Finally, we confirmed previous findings that L74V-containing viruses display diminished replication capacity and that this is associated with reduced levels of synthesis of early reverse-transcribed viral DNA molecules.

Abstract: In addition, we determined that the L74V and M184V mutations did not affect the ratio between the populations of RT-DNA/DNA complexes found at pre- and posttranslocational stages; however, they might have affected proper alignment between incorporated chain terminator and pyrophosphate donor, substrate orientation, affinity for ATP, and/or primer-template substrate.

Abstract: The L74V and M184V mutations in the reverse transcriptase (RT) gene of human immunodeficiency vir

Comparison of tests and procedures to build clinically relevant genotypic scores: application to the Jaguar study.

PMID: 16038473 2005 Antiviral therapy

Abstract: RESULTS: Eight mutations were associated with a reduced virological response to ddI: M41L, D67N, T69D, L74V, V1181, L210W, T215Y/F and K219Q/E and two mutations with a better virological response: K70R and M184V/I.

Abstract: The Jonckheere-Terpstra test for trend provided the combination of mutations (M41L+T69D-K70R+L74V-M184V /I+T215Y/F+ K219A/E) that were the most predictive for the week 4 virologi

Efficacy and safety of once-daily combination therapy with didanosine, lamivudine and nevirapine in antiretroviral-naive HIV-infected patients.

PMID: 16152754 2005 Antiviral therapy

Abstract: Eight out of nine patients with available genotype after virological failure showed resistance mutations to NVP (Y181C and others) and 3TC (M184V/I), and four of them also had ddI resistance (L74V).

HIV-1 reverse transcriptase mutations that confer decreased in vitro susceptibility to anti-RT DNA aptamer RT1t49 confer cross resistance to other anti-RT aptamers but not to standard RT inhibitors.

PMID: 16207371 2005 AIDS research and therapy

Result: Variants of HIV-1 RT shown to confer resistance to AZT (T215Y/M41L) and ddI and ddC (L74V) were sensitive to inhibition by RT1t49 (Table 3).

Table: L74V

Discussion: The results of RT1t49 susceptibility testing (Table 3) with the ddI/ddC-resistant L74V, 3TC-resistant M184V and the AZT-resistant T215Y/M41L RTs are in agreement with our previously published efficacy tests using Jurkat T cell lines expressing each of the three selected anti-RT RNA aptamers, in which all the RNA aptamers were able to efficiently suppress replication of drug-resistant HIV.

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